GEO DataSets

(Submitter supplied) IMV induces transcription of key glycolytic enzymes in alveolar epithelial type II mice IMV induced transcription of key glycolytic enzymes is HIF1A dependent

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL32912

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by high throughput sequencing; Expression profiling by RT-PCR

Platforms:

GPL17837 GPL27943

31 Samples

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(Submitter supplied) The study describes miRNA expression changes in basal ganglia (BG) of chronically SIV-infected rhesus macaques. HIV/SIV-associated neurological disorder (HAND) represents a major comorbidity affecting HIV patients on anti-retroviral therapy. Employing a systems biology approach, we report molecular changes underlying HAND and its modulation by phytocannabinoids [delta-9-tetrahydrocannabinol (9-THC)] in uninfected and SIV-infected rhesus macaques (RMs) treated with vehicle (VEH/SIV) or 9-THC (THC/SIV). more...

Organism:

Macaca mulatta; Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL17837

14 Samples

Download data: TXT

(Submitter supplied) We pre-treated human periodontal ligament stem cells (hPDLSCs) under Iinterleukin-6 (IL-6) in osteogenic inductive medium (OM) on osteogenic differentiation potential and investigate the specific signaling pathway by clarifying with several antagonists (Dkk-1, SP600125, SB431542, and DAPT) and siRNA (siWnt2B, siWnt10B, and siWnt5A) to identify the differences in the expression pattern of osteogenic related markers by reverse transcription quantitative polymerase chain reaction (RT-qPCR).

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL33139

40 Samples

Download data: TXT

(Submitter supplied) the impact of different concentration of ZnO NPs on the relative gene expression of QS-regulatory genes

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by RT-PCR

Platform:

GPL33136

3 Samples

Download data: TXT

(Submitter supplied) Placenta junctional zone and brains dissected, kept in -80ºC, RNA extracted with RNAesasy kit kiagen, cDNA performed with normalized RNA levels. qPCR gene expression profiling

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL33099

35 Samples

Download data: TXT

(Submitter supplied) First-line treatment for osteosarcoma includes chemotherapy and surgery. However, the five-year survival rate of refractory osteosarcoma remains unsatisfactory. Osteosarcoma cancer stem cells, possessing stemness and chemoresistance, are one of the critical causes for poor response to chemotherapy. Elucidating regulatory signaling pathways of osteosarcoma cancer stem cells may provide a rationale for improving regimens against chemoresistant osteosarcoma. more...

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL33063

6 Samples

Download data: XLSX

(Submitter supplied) PCR array data for expresion of Cancer Stem Cell genes in A375M and FO1 cells after 24h and 96h growth

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL30889

8 Samples

Download data: TXT, XLSX

(Submitter supplied) HK-2 cells were cultured in low and high glucose conditions for 96 hours in serum free conditions. Exosomes were isolated from the supernatant of these cells. miRCURY LNATM Universal RT microRNA PCR Human panel I+II (Exiqon) were used to study the differential expression from three different high glucose treated exosomes (HE1, HE2, HE3) than to low glucose treated exosomes (LE1, LE2, LE3).

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL30410

6 Samples

Download data: TXT

(Submitter supplied) New early low-invasive biomarkers are demanded for the management of Oligoarticular Juvenile Idiopathic Arthritis (OJIA), the most common chronic inflammatory arthritis in childhood and a leading cause of disability. Extracellular vesicles (EVs) released in the synovial fluid (SF) of inflamed joints have gained increased recognition as mediators of arthritis pathogenesis and as a source of biomarkers. more...

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL19079

24 Samples

Download data: TXT

(Submitter supplied) The rostral ventrolateral medulla (RVLM), a part of the medullary reticular formation, plays a major role in several physiological responses, including cardiovascular and sympathetic nervous system functions. Although aging causes disturbances in the responses of these physiological systems, RVLM involvement in these age-related changes is not clear. Previous work using high-throughput gene expression analysis of the RVLM in aged animals suggested that chemical neurotransmission-related genes might be downregulated with advancing age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by RT-PCR

Platform:

GPL32921

26 Samples

Download data: XLSX

(Submitter supplied) COPD is a heterogeneous condition without effective disease modifying therapies. Identification of novel inflammatory endotype markers such as extracellular vesicles (EVs), which are important intercellular messengers carrying microRNA (miRNA), may enable earlier diagnosis and disease stratification for a targeted treatment approach. Our aim was to identify differentially expressed EV miRNA in the lungs of COPD patients compared with healthy ex-smokers and determine whether they can help define inflammatory COPD endotypes. more...

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL32872

44 Samples

Download data: TXT, XLSX

(Submitter supplied) Total RNA was isolated from GFAP::GFP+CD133+EGFR-CD24- (quiescent neural stem cells, qNSCs), GFAP::GFP+CD133+EGFR+CD24- (activated neural stem cells, aNSCs) and GFAP::GFP+CD133- EGFR+CD24- (transit amplifying cells, TACs) cells from the adult mouse ventricular-subventricular zone (V-SVZ) (GFAP::GFP mice, Jackson Mice Stock number 003257).

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL17017

8 Samples

Download data: XLSX

(Submitter supplied) Study #1: U266 cells were treated with 100 nM PF477736 for 4 hr. Study #2: U266 cells were treated with 100 nM PF477736 for 16 hr. Study #3: KAS/6-1 cells were treated with 50 nM PF477736 or 300 nM CEP3891 for 2 hr.

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL30133

7 Samples

Download data: TXT

(Submitter supplied) Age-matched K18-hACE2 transgenic mice were passively transferred with human COVID-19 mRNA post-vaccination (post-vac) sera followed by the lethal challenge with different SARS-CoV-2 viruses via intranasal route, including (1) New York-PV09158/2020 (NY) of lineage B.1.3 bearing 614G, (2) Kappa (B.1.617.1) and (3) Delta (B.1.617.2). Mouse lungs were harvested on 5 days post infection (dpi). Total RNA was extracted using QIAgen RNeasy Plus Mini Kit and was reverse transcribed using the High-Capacity cDNA Reverse Transcription Kit (Thermo Fisher Scientific). more...

Organism:

Mus musculus

Type:

Expression profiling by RT-PCR

Platform:

GPL30599

39 Samples

Download data: TXT

(Submitter supplied) We report miRNA profiling in patients with Alström syndrome (ALMS) and Bardet-Biedl syndrome (BBS). The aim of this study was to determine if the expression of circulating miRNAs in patients with ALMS and BBS differs from that in healthy and obese individuals and determine if miRNA levels correlate with metabolic tests, BMI-SDS and patient age.

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL26335

62 Samples

Download data: XLS

(Submitter supplied) At present, there is no effective treatment for diabetic wounds, and the cost of treatment is high. MicroRNAs (miRNAs) plays an important role in the process of diabetic wound healing. By regulating the expression of target genes, it regulates growth factors, cytokines and signal pathways, thereby affecting various stages of ulcer healing such as hemostasis, anti-inflammatory, proliferation and remodeling. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array; Expression profiling by RT-PCR

Platform:

GPL30951

6 Samples

Download data: TXT

(Submitter supplied) Context: Gastrointestinal stromal tumors (GISTs) harboring mutations in the PDGFRA gene occur in only about 5–7% of patients. The most common PDGFRA mutation is exon 18 D842V, which is corre-lated with specific clinico-pathological features compared to the other PDGFRA mutated GISTs. Herein, we present a miRNA expression profile comparison of PDGFRA D842V mutant GISTs and PDGFRA with mutations other than D842V (non-D842V). more...

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL32743

10 Samples

Download data: XLSX

(Submitter supplied) Background/aims: Lung carcinoids are uncommon neuroendocrine tumours. Molecular features of lung carcinoids have been poorly defined. microRNAs (miRNAs) are potent gene expression regulators with important roles in cancer development and progression. However, little is known on the role of miRNAs in the pathogenesis of lung carcinoids. Our goals were to identify commonly deregulated miRNAs in a rare case of lung carcinoid of typical histology with metastasis, as well as map miRNA target genes in pathways potentially associated with disease development and progression. more...

Organism:

Homo sapiens

Type:

Expression profiling by RT-PCR

Platform:

GPL18942

6 Samples

Download data: TXT

(Submitter supplied) Tree improvement programs select genotypes for faster growth, at both early and late stages, to increase yields over unimproved material, and the improvement is frequently attributed to genetic control in growth parameters among genotypes. Underutilized genetic variability among genotypes also has the potential to ensure future gains are possible. However, the genetic variation in growth, physiology and hormone control among genotypes generated from different breeding strategies has not been well characterized in conifers. more...

Organism:

Picea glauca

Type:

Expression profiling by RT-PCR

Platform:

GPL32694

69 Samples

Download data: XLSX