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Items: 1 to 20 of 385

1.

A heterodimer of α and β hemoglobin chains functions as an innate anticancer agent

(Submitter supplied) Metastatic (as well as tumor) microenvironments contain both cancer-promoting as well as cancer restraining factors. The balance between these opposing forces determines the fate of cancer cells that disseminate to secondary organ sites. In search for microenvironmental drivers or inhibitors of metastasis, we identified, in a previous study, the beta subunit of hemoglobin (HBB) as a lung-derived antimetastatic factor. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL33134
24 Samples
Download data: XLSX
Series
Accession:
GSE225459
ID:
200225459
2.

YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Protein profiling by protein array
Platforms:
GPL33200 GPL18573
47 Samples
Download data
Series
Accession:
GSE226357
ID:
200226357
3.

YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells [RPPA]

(Submitter supplied) In heterogeneous head and neck cancer (HNC), subtype-specific treatment regimens are currently missing. An integrated analysis of patient HNC subtypes using single-cell sequencing and proteome profiles revealed an epithelial-mesenchymal transition (EMT) signature within the epithelial cancer-cell population. The EMT signature coincided with PI3K/mTOR inactivation in the mesenchymal subtype. Conversely, the signature was suppressed in epithelial cells of the basal subtype which exhibits hyperactive PI3K/mTOR signalling. more...
Organism:
Homo sapiens; Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL33200
32 Samples
Download data: XLSX
Series
Accession:
GSE226356
ID:
200226356
4.

COVID-19 drives a distinct plasma proteome in pregnant and non-pregnant individuals

(Submitter supplied) This study used SomaScan v 4.1 to profile>7000 proteins in human plasma and assess changes with Sars-Cov-2 infection and with Covid-19 disease severity in pregnant and non-pregnant individuals.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL32354
194 Samples
Download data
Series
Accession:
GSE207015
ID:
200207015
5.

Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Sus scrofa; Escherichia coli; Triticum aestivum; Spodoptera frugiperda; Bos taurus; Homo sapiens; Capra hircus
Type:
Protein profiling by protein array
Platforms:
GPL33017 GPL33018
710 Samples
Download data
Series
Accession:
GSE222765
ID:
200222765
6.

Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness [CTD]

(Submitter supplied) We used protein arrays to measure IgG autoantibodies associated with Connective Tissue Diseases (CTDs) and Anti-Cytokine Antibodies (ACA) in patients with non-COVID-19 infections such as influenza
Organism:
Sus scrofa; Homo sapiens; Triticum aestivum; Spodoptera frugiperda; Bos taurus; Capra hircus; Escherichia coli
Type:
Protein profiling by protein array
Platform:
GPL33018
355 Samples
Download data: XLSX
Series
Accession:
GSE222764
ID:
200222764
7.

Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness [ACA]

(Submitter supplied) We used protein arrays to measure IgG autoantibodies associated with Connective Tissue Diseases (CTDs) and Anti-Cytokine Antibodies (ACA) in patients with non-COVID-19 infections such as influenza
Organism:
Homo sapiens; Escherichia coli
Type:
Protein profiling by protein array
Platform:
GPL33017
355 Samples
Download data: XLSX
Series
Accession:
GSE222760
ID:
200222760
8.

Effect of human beta defensin-2 (hBD-2) on T cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Protein profiling by protein array
Platforms:
GPL32036 GPL32056
10 Samples
Download data: XLSX
Series
Accession:
GSE198405
ID:
200198405
9.

Effect of human beta defensin-2 (hBD-2) on T cells [mouse]

(Submitter supplied) In this experiment, we studied how human beta defensin-2 (hBD-2) affects kinase activity of T cells.
Organism:
Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL32056
4 Samples
Download data: XLSX
Series
Accession:
GSE198404
ID:
200198404
10.

Effect of human beta defensin-2 (hBD-2) on T cells [human]

(Submitter supplied) In this experiment, we studied how human beta defensin-2 (hBD-2) affects kinase activity of T cells.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL32036
6 Samples
Download data: XLSX
Series
Accession:
GSE198402
ID:
200198402
11.

Cytokines in the ApoE-/- mice atherosclerotic plaque

(Submitter supplied) To identify the dynamic changes of cytokines in the ApoE-/- mice atherosclerotic plaque, heart, and serum upon β-adrenergic stimulation (isoproterenol, 5 mg/kg body weight) at 0.5hrs, 1hrs, 3hrs and 24hrs using mouse cytokine antibody arrays.
Organism:
Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL32918
45 Samples
Download data: TXT
Series
Accession:
GSE220225
ID:
200220225
12.

IgG profiling using AIT’s 16k protein microarray’ for elucidating the IgG profile of a memory-B cells and a “Novel” cell population

(Submitter supplied) Plasma cells are not restricted to the CD27+ phenotype: characterization of CD27-CD43+ antibody secreting cells. Circulating antibody secreting cells are present in peripheral blood of healthy individuals reflecting continued activity of the humoral immune system. Antibody secreting cells typically express CD27. We describe and characterize a small population of antibody secreting class switched CD19+CD43+ B cells that lack expression of CD27 in peripheral blood of healthy subjects. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL32854
7 Samples
Download data: TXT
Series
Accession:
GSE217855
ID:
200217855
13.

CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease

(Submitter supplied) Idiopathic multicentric Castleman disease (iMCD) is a rare and poorly-understood cytokine storm-driven inflammatory disorder. Interleukin-6 (IL-6) is a known disease driver in some patients, but anti-IL-6 therapy with siltuximab is not effective in all patients, and biomarkers indicating success at an early time point following treatment initiation are lacking. Here we show, by comparison of levels of 1,178 proteins in sera of healthy participants (N=42), patients with iMCD (N=88), and with related diseases (N=60), a comprehensive landscape of candidate disease mediators and predictors of siltuximab response. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL23119
368 Samples
Download data: TXT
Series
Accession:
GSE217351
ID:
200217351
14.

Human Plasma Proteome During Normal Pregnancy

(Submitter supplied) This study used SomaScan v 4.1 to profile>7000 proteins in maternal plasma and asses changes with gestational age and maternal characteristics. The study proposed models to estimate the expected protein abundance so that future datasets can be normalized agains these expected value to obtain Multiples of the Mean values.
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL32354
519 Samples
Download data
Series
Accession:
GSE206454
ID:
200206454
15.

The amniotic fluid proteome improves prediction of imminent delivery relative to quantitative cervical length: a cross-sectional study in women with a short cervix

(Submitter supplied) For women identified as at risk for preterm birth attributable to a sonographic short cervix, the determination of imminent delivery is crucial for patient management. The current study aimed to identify amniotic fluid proteins that could predict imminent delivery in asymptomatic patients with a short cervix. An aptamer-based multiplex platform was used to profile 1,310 AF proteins, and the significance of protein dysregulation was determined by moderated t-tests between women who destined to deliver within two weeks of amnicentesis. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL23119
106 Samples
Download data
Series
Accession:
GSE186135
ID:
200186135
16.

Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomized, phase 3 trial.

(Submitter supplied) The TeloVac study indicated that GV1001 did not to improve the survival of advanced pancreatic ductal adenocarcinoma (PDAC) patients. However, the cytokine examinations of the study suggested that high serum eotaxin levels may predict responses to GV1001. This phase III trial aimed to assess the efficacy of GV1001 with gemcitabine/capecitabine for eotaxin-high patients with untreated locally advanced and metastatic PDAC. more...
Organism:
Homo sapiens
Type:
Protein profiling by protein array
Platform:
GPL32338
73 Samples
Download data: GPR, XLSX
Series
Accession:
GSE212575
ID:
200212575
17.

TLR7 agonism accelerates disease in a mouse model of primary Sjögren’s syndrome and drives expansion of age-associated B cells

(Submitter supplied) Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by chronic inflammation of exocrine tissue, resulting in loss of tears and saliva. Patients also experience many extra-glandular disease manifestations. Treatment for pSS is palliative, and there are currently no treatments available that target disease etiology. Previous studies in our lab demonstrated that Myd88 is crucial for pSS pathogenesis in the NOD.B10Sn-H2b (NOD.B10) pSS mouse model, although the way in which Myd88-dependent pathways become activated in disease remains unknown. more...
Organism:
Mus musculus; synthetic construct
Type:
Protein profiling by protein array
Platform:
GPL29507
64 Samples
Download data: GPR, XLSX
Series
Accession:
GSE212467
ID:
200212467
18.

Chemokines profiling in tumors treated with UNC1999

(Submitter supplied) Increased expression of chemokines in UNC1999-treated tumor tissues were successfully checked out through chemokines profiles screening of a total 25 different mouse chemokines using control and UNC1999-treated tumor tissues.
Organism:
Mus musculus
Type:
Protein profiling by protein array
Platform:
GPL32591
8 Samples
Download data: XLSX
Series
Accession:
GSE211880
ID:
200211880
19.

The antibody landscapes against Group 1 and 2 influenza virus hemagglutinin following AS03 and MF59 adjuvanted H5N1 vaccination

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Influenza A virus; Influenza B virus
Type:
Protein profiling by protein array
Platforms:
GPL32237 GPL32236
3420 Samples
Download data
Series
Accession:
GSE202392
ID:
200202392
20.

The antibody landscapes against Group 1 and 2 influenza virus hemagglutinin following AS03 and MF59 adjuvanted H5N1 vaccination (probing_4_igg)

(Submitter supplied) Current seasonal and pre-pandemic influenza vaccines induce short-lived predominantly strain-specific and limited heterosubtypic responses. To better understand how vaccine adjuvants AS03 and MF59 may provide improved antibody responses to vaccination, we interrogated serum from subjects who received 2 doses of inactivated monovalent influenza A/Indonesia/05/2005 vaccine with or without AS03 or MF59 using hemagglutinin (HA) microarrays (NCT01317758 and NCT01317745). more...
Organism:
Homo sapiens; Influenza A virus; Influenza B virus
Type:
Protein profiling by protein array
Platform:
GPL32237
450 Samples
Download data: CSV, TXT
Series
Accession:
GSE202390
ID:
200202390
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