PYGM glycogen phosphorylase, muscle associated [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: PYGM
Gene description: glycogen phosphorylase, muscle associated
See related: Ensembl:ENSOCUG00000002173
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	Unplaced Scaffold	NW_026258873.1 (15684..25973)

NW_026258873.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NW_026258873 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of arginine on stability and aggregation of muscle glycogen phosphorylase b.
Title: Effect of arginine on stability and aggregation of muscle glycogen phosphorylase b.
These results suggest that some conformational changes have taken place in the maltooligosaccharide-binding region of the GP catalytic site during allosteric regulation.
Title: Probing the catalytic site of rabbit muscle glycogen phosphorylase using a series of specifically modified maltohexaose derivatives.
The formation of a complex between the denatured monomeric form of Phb and the dissociated forms of GroEL is detected during heating at 46 degrees C.
Title: Effect of GroEL on thermal aggregation of glycogen phosphorylase b from rabbit skeletal muscle.
alpha-crystallin interacts with the intermediates of unfolding of the Phb molecule
Title: Kinetics of thermal aggregation of glycogen phosphorylase b from rabbit skeletal muscle: mechanism of protective action of alpha-crystallin.

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General gene information

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Markers

ECD02084 (e-PCR)
- UniSTS:283185

PYGM (e-PCR)
- UniSTS:504720

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glycogen catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glycogen phosphorylase, muscle form

Names: myophosphorylase; phosphorylase, glycogen, muscle

NP_001075653.1

EC 2.4.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082184.1 → NP_001075653.1 glycogen phosphorylase, muscle form

See identical proteins and their annotated locations for NP_001075653.1

Status: PROVISIONAL

Source sequence(s)

X04265

UniProtKB/Swiss-Prot

P00489

UniProtKB/TrEMBL

B7NZI0

Related

ENSOCUP00000001880.3, ENSOCUT00000002177.3

Conserved Domains (2) summary

cd04300
Location:29 → 828

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:32 → 828

P_ylase; glycogen/starch/alpha-glucan phosphorylases