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Zbtb48 zinc finger and BTB domain containing 48 [ Mus musculus (house mouse) ]

Gene ID: 100090, updated on 28-Oct-2024

Summary

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Official Symbol
Zbtb48provided by MGI
Official Full Name
zinc finger and BTB domain containing 48provided by MGI
Primary source
MGI:MGI:2140248
See related
Ensembl:ENSMUSG00000028952 AllianceGenome:MGI:2140248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hkr3; TZAP; 0610011D15Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; and telomere maintenance via telomere lengthening. Predicted to be located in chromosome, telomeric region. Predicted to be active in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZBTB48 (zinc finger and BTB domain containing 48). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 8.7), limb E14.5 (RPKM 7.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb48 in Genome Data Viewer
Location:
4 E2; 4 82.83 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152104230..152112132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152019773..152027675, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6290 Neighboring gene PHD finger protein 13 Neighboring gene STARR-positive B cell enhancer ABC_E3557 Neighboring gene kelch-like 21 Neighboring gene STARR-positive B cell enhancer ABC_E6291 Neighboring gene STARR-seq mESC enhancer starr_12192 Neighboring gene taste receptor, type 1, member 1 Neighboring gene nucleolar protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded telomeric DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomere lengthening ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
telomere zinc finger-associated protein
Names
GLI-Krueppel family member HKR3
GLI-Kruppel family member HKR3
Krueppel-related zinc finger protein 3 homolog
zinc finger and BTB domain-containing protein 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379628.1 → NP_001366557.1  telomere zinc finger-associated protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 1, encodes the functional protein.
    Source sequence(s)
    AL611927
    UniProtKB/Swiss-Prot
    A2A8B1, Q1H9T6, Q99K15
    Conserved Domains (7) summary
    COG5048
    Location:456 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:367 → 452
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:402 → 418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18232
    Location:8 → 115
    BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
    pfam00096
    Location:571 → 593
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:298 → 321
    zf-H2C2_2; Zinc-finger double domain

  2. NM_133879.3 → NP_598640.2  telomere zinc finger-associated protein

    See identical proteins and their annotated locations for NP_598640.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 2, encodes the functional protein.
    Source sequence(s)
    AL611927
    Consensus CDS
    CCDS38982.1
    UniProtKB/Swiss-Prot
    A2A8B1, Q1H9T6, Q99K15
    Related
    ENSMUSP00000067521.5, ENSMUST00000066715.11
    Conserved Domains (7) summary
    COG5048
    Location:456 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:367 → 452
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:402 → 418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18232
    Location:8 → 115
    BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
    pfam00096
    Location:571 → 593
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:298 → 321
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_166858.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611927
    Related
    ENSMUST00000155389.8

  2. NR_166859.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611927

  3. NR_166860.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL611927
    Related
    ENSMUST00000123696.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152104230..152112132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538448.2 → XP_006538511.1  telomere zinc finger-associated protein isoform X2

    See identical proteins and their annotated locations for XP_006538511.1

    Conserved Domains (5) summary
    PHA03247
    Location:396 → 553
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:627 → 649
    zf-C2H2; Zinc finger, C2H2 type
    cd18232
    Location:8 → 115
    BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
    pfam13465
    Location:298 → 321
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006538449.1 → XP_006538512.1  telomere zinc finger-associated protein isoform X2

    See identical proteins and their annotated locations for XP_006538512.1

    Conserved Domains (5) summary
    PHA03247
    Location:396 → 553
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:627 → 649
    zf-C2H2; Zinc finger, C2H2 type
    cd18232
    Location:8 → 115
    BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
    pfam13465
    Location:298 → 321
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017319884.2 → XP_017175373.1  telomere zinc finger-associated protein isoform X3

    Conserved Domains (7) summary
    COG5048
    Location:486 → 547
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:397 → 482
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:432 → 448
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:601 → 623
    zf-C2H2; Zinc finger, C2H2 type
    cd18232
    Location:38 → 145
    BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
    pfam13465
    Location:328 → 351
    zf-H2C2_2; Zinc-finger double domain

  4. XM_017319883.2 → XP_017175372.1  telomere zinc finger-associated protein isoform X1

    Conserved Domains (5) summary
    PHA03247
    Location:426 → 583
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:316 → 336
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:657 → 679
    zf-C2H2; Zinc finger, C2H2 type
    cd18232
    Location:38 → 145
    BTB_POZ_ZBTB48_TZAP_KR3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP)
    pfam13465
    Location:328 → 351
    zf-H2C2_2; Zinc-finger double domain

  5. XM_006538451.4 → XP_006538514.1  telomere zinc finger-associated protein isoform X4

    Conserved Domains (5) summary
    COG5048
    Location:121 → 182
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:32 → 117
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:125 → 145
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:236 → 258
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:223 → 247
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_003954859.1 RNA Sequence

  2. XR_003954858.2 RNA Sequence

  3. XR_004941792.1 RNA Sequence

  4. XR_003954857.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1H9T6.1 GenPept UniProtKB/Swiss-Prot:Q1H9T6

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