U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MCTS2 MCTS family member 2 [ Homo sapiens (human) ]

Gene ID: 100101490, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
MCTS2provided by HGNC
Official Full Name
MCTS family member 2provided by HGNC
Primary source
HGNC:HGNC:49760
See related
Ensembl:ENSG00000101898 MIM:620406; AllianceGenome:HGNC:49760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCTS2P; PSIMCT-1
Summary
This locus represents a retrogene copy of MCTS1 (GeneID:28985) and contains an ORF similar to that parent gene. This locus is situated in a differentially methylated region (DMR) and transcripts in this region are imprinted. [provided by RefSeq, Nov 2021]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
20q11.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31547379..31548081)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33271603..33272305)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30135182..30135884)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ser (anticodon AGA) 7-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12757 Neighboring gene CD24 molecule pseudogene 3 Neighboring gene histocompatibility minor 13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:30134937-30136136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30137639-30138140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30138141-30138640 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30142553-30143052 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:30148388-30149587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30153591-30154466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30154467-30155342 Neighboring gene Sharpr-MPRA regulatory region 9809 Neighboring gene HM13 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30160423-30160964 Neighboring gene uncharacterized LOC107985416 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30162848-30163017 Neighboring gene RNA, U6 small nuclear 384, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of the MCT-1 pseudogene: identification and implication of its location in a highly amplified region of chromosome 20. Nandi S, et al. Biochim Biophys Acta, 2006 May. PMID 16815567
  2. Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment. Court F, et al. Genome Res, 2014 Apr. PMID 24402520, Free PMC Article
  3. Array-based DNA methylation analysis in individuals with developmental delay/intellectual disability and normal molecular karyotype. Kolarova J, et al. Eur J Med Genet, 2015 Aug. PMID 26003415
  4. A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation. Wood AJ, et al. PLoS Genet, 2007 Feb 9. PMID 17291163, Free PMC Article
  5. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. Yuan J, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36244648, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A pseudogene for MCT-1 (PsiMCT-1) that is located on chromosome 20q11.2 was identified.
    Title: Characterization of the MCT-1 pseudogene: identification and implication of its location in a highly amplified region of chromosome 20.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
malignant T-cell-amplified sequence 2
Names
MCTS family member 2, pseudogene
malignant T cell amplified sequence 1 pseudogene
malignant T cell amplified sequence 2, pseudogene

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397496.1 → NP_001384425.1  malignant T-cell-amplified sequence 2

    Status: VALIDATED

    Source sequence(s)
    AL110115
    Consensus CDS
    CCDS93025.1
    UniProtKB/Swiss-Prot
    A0A3B3IRV3
    Related
    ENSP00000496921.1, ENST00000394552.4
    Conserved Domains (2) summary
    cd11609
    Location:4 → 80
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:80 → 175
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    31547379..31548081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    33271603..33272305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_045217.2: Suppressed sequence

    Description
    NG_045217.2: This RefSeq was removed because it is now thought that this gene does encode a protein.

  2. NR_003677.1: Suppressed sequence

    Description
    NR_003677.1: This RefSeq was removed because there is insufficient evidence that this locus is transcribed independently of GeneID:81502.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A3B3IRV3.1 GenPept UniProtKB/Swiss-Prot:A0A3B3IRV3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous