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Dnah7c dynein, axonemal, heavy chain 7C [ Mus musculus (house mouse) ]

Gene ID: 100101919, updated on 2-Nov-2024

Summary

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Official Symbol
Dnah7cprovided by MGI
Official Full Name
dynein, axonemal, heavy chain 7Cprovided by MGI
Primary source
MGI:MGI:3639762
See related
Ensembl:ENSMUSG00000101337 AllianceGenome:MGI:3639762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnahc7c
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement and inner dynein arm assembly. Predicted to be located in cytosol. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in spermatozoon and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 4.9), CNS E18 (RPKM 0.3) and 4 other tissues See more
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Genomic context

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See Dnah7c in Genome Data Viewer
Location:
1 C1.1; 1 24.0 cM
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (46464590..46846637)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (46425428..46807477)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00828 Neighboring gene nuclear encoded rRNA 5S 211 Neighboring gene heat shock protein 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00829 Neighboring gene STARR-seq mESC enhancer starr_00830 Neighboring gene STARR-positive B cell enhancer mm9_chr1:46910886-46911186 Neighboring gene STARR-positive B cell enhancer mm9_chr1:46910239-46910540 Neighboring gene solute carrier family 39 (zinc transporter), member 10 Neighboring gene STARR-seq mESC enhancer starr_00836 Neighboring gene STARR-seq mESC enhancer starr_00838 Neighboring gene STARR-seq mESC enhancer starr_00839 Neighboring gene STARR-seq mESC enhancer starr_00842 Neighboring gene STARR-seq mESC enhancer starr_00843 Neighboring gene STARR-seq mESC enhancer starr_00844 Neighboring gene STARR-seq mESC enhancer starr_00845 Neighboring gene predicted gene, 39638

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. Dong F, et al. J Cell Biol, 2014 Jan 20. PMID 24421334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium movement ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inner dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of inner dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner dynein arm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein, axonemal, heavy chain 7C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310335.1 → NP_001297264.1  dynein, axonemal, heavy chain 7C

    Status: VALIDATED

    Source sequence(s)
    AC122879, AC124185, AC163216
    Consensus CDS
    CCDS78579.1
    UniProtKB/TrEMBL
    A0A087WR13, L7N1Y0
    Related
    ENSMUSP00000140430.2, ENSMUST00000189749.7
    Conserved Domains (5) summary
    pfam03028
    Location:3318 → 4012
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:759 → 1163
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:2587 → 2933
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:2963 → 3178
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1290 → 1520
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    46464590..46846637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238631.4 → XP_011236933.1  dynein, axonemal, heavy chain 7C isoform X1

    UniProtKB/TrEMBL
    L7N1Y0
    Conserved Domains (6) summary
    COG5245
    Location:959 → 3690
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:757 → 1162
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1290 → 1640
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2335 → 2595
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:2987 → 3203
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:3744 → 4044
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_006496387.5 → XP_006496450.1  dynein, axonemal, heavy chain 7C isoform X2

    Conserved Domains (6) summary
    COG5245
    Location:86 → 2087
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam12774
    Location:1 → 37
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12775
    Location:359 → 539
    AAA_7; P-loop containing dynein motor region D3
    pfam12780
    Location:732 → 992
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:1384 → 1600
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:2141 → 2441
    Dynein_C; Dynein heavy chain C-terminal domain
Nucleotide Protein
Heading Accession and Version

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