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MKRN2OS MKRN2 opposite strand [ Homo sapiens (human) ]

Gene ID: 100129480, updated on 8-Mar-2024

Summary

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Official Symbol
MKRN2OSprovided by HGNC
Official Full Name
MKRN2 opposite strandprovided by HGNC
Primary source
HGNC:HGNC:40375
See related
Ensembl:ENSG00000225526 AllianceGenome:HGNC:40375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf83; MKRN2-AS1
Expression
Broad expression in small intestine (RPKM 1.1), duodenum (RPKM 1.1) and 22 other tissues See more
Orthologs
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Genomic context

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See MKRN2OS in Genome Data Viewer
Location:
3p25.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (12539776..12560999, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (12537578..12558803, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12581275..12602498, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:12558643-12559143 Neighboring gene RNA, 5S ribosomal pseudogene 123 Neighboring gene RNA, U6 small nuclear 377, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14065 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12598813-12599336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19446 Neighboring gene makorin ring finger protein 2 Neighboring gene MPRA-validated peak4543 silencer Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase Neighboring gene small nucleolar RNA U13 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:12684584-12684794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12698025-12698668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12704698-12705308 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12705309-12705920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12711892-12712473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12712474-12713054 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:12715375-12716244 Neighboring gene cysteine rich protein 1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The DNA sequence, annotation and analysis of human chromosome 3. Muzny DM, et al. Nature, 2006 Apr 27. PMID 16641997
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
MKRN2 opposite strand protein
Names
MKRN2 antisense RNA 1 (non-protein coding)
MKRN2 antisense gene protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195279.2 → NP_001182208.1  MKRN2 opposite strand protein isoform 1

    See identical proteins and their annotated locations for NP_001182208.1

    Status: VALIDATED

    Source sequence(s)
    AC018500
    Consensus CDS
    CCDS58816.1
    UniProtKB/Swiss-Prot
    H3BPM6
    Related
    ENSP00000455385.3, ENST00000564146.4
    Conserved Domains (1) summary
    pfam16044
    Location:8 → 199
    DUF4796; Domain of unknown function (DUF4796)

  2. NM_001378007.1 → NP_001364936.1  MKRN2 opposite strand protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC018500
    Conserved Domains (1) summary
    pfam16044
    Location:1 → 80
    DUF4796; Domain of unknown function (DUF4796)

  3. NM_001378008.1 → NP_001364937.1  MKRN2 opposite strand protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC018500
    Conserved Domains (1) summary
    pfam16044
    Location:1 → 80
    DUF4796; Domain of unknown function (DUF4796)

  4. NM_001378009.1 → NP_001364938.1  MKRN2 opposite strand protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC018500
    Conserved Domains (1) summary
    pfam16044
    Location:1 → 80
    DUF4796; Domain of unknown function (DUF4796)

  5. NM_001378010.1 → NP_001364939.1  MKRN2 opposite strand protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018500
    Conserved Domains (1) summary
    pfam16044
    Location:20 → 129
    DUF4796; Domain of unknown function (DUF4796)

  6. NM_001378011.1 → NP_001364940.1  MKRN2 opposite strand protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC018500
    Conserved Domains (1) summary
    pfam16044
    Location:8 → 176
    DUF4796; Domain of unknown function (DUF4796)

RNA

  1. NR_165360.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC018500

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    12539776..12560999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533242.4 → XP_011531544.1  MKRN2 opposite strand protein isoform X1

    See identical proteins and their annotated locations for XP_011531544.1

    Conserved Domains (1) summary
    pfam16044
    Location:1 → 80
    DUF4796; Domain of unknown function (DUF4796)

  2. XM_011533243.4 → XP_011531545.1  MKRN2 opposite strand protein isoform X1

    See identical proteins and their annotated locations for XP_011531545.1

    Conserved Domains (1) summary
    pfam16044
    Location:1 → 80
    DUF4796; Domain of unknown function (DUF4796)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    12537578..12558803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344805.1 → XP_054200780.1  MKRN2 opposite strand protein isoform X1

  2. XM_054344806.1 → XP_054200781.1  MKRN2 opposite strand protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H3BPM6.1 GenPept UniProtKB/Swiss-Prot:H3BPM6

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