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ZNF316 zinc finger protein 316 [ Homo sapiens (human) ]

Gene ID: 100131017, updated on 8-Mar-2024

Summary

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Official Symbol
ZNF316provided by HGNC
Official Full Name
zinc finger protein 316provided by HGNC
Primary source
HGNC:HGNC:13843
See related
Ensembl:ENSG00000205903 AllianceGenome:HGNC:13843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MZF-3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 6.9), fat (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF316 in Genome Data Viewer
Location:
7p22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6637318..6658279)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6756509..6777459)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6676949..6697910)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6628794-6629632 Neighboring gene integrator complex subunit 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:6637314-6637506 Neighboring gene Sharpr-MPRA regulatory region 9377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6653371-6654124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6654125-6654878 Neighboring gene zinc finger protein 853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6663565-6664065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25632 Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6698799-6699300 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6703791-6704291 Neighboring gene uncharacterized LOC124901583 Neighboring gene zinc finger protein 33B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A quantitative atlas of mitotic phosphorylation. Dephoure N, et al. Proc Natl Acad Sci U S A, 2008 Aug 5. PMID 18669648, Free PMC Article
  2. Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells. Yang Z, et al. Vaccines (Basel), 2022 Nov 29. PMID 36560452, Free PMC Article
  3. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Gupta R, et al. Cell, 2018 May 3. PMID 29656893, Free PMC Article
  4. A High-Density Map for Navigating the Human Polycomb Complexome. Hauri S, et al. Cell Rep, 2016 Oct 4. PMID 27705803
  5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686B2320

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 316

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278559.2 → NP_001265488.1  zinc finger protein 316

    See identical proteins and their annotated locations for NP_001265488.1

    Status: VALIDATED

    Source sequence(s)
    AC073343
    Consensus CDS
    CCDS75563.1
    UniProtKB/Swiss-Prot
    A6NFI3
    Related
    ENSP00000477706.1, ENST00000382252.6
    Conserved Domains (4) summary
    smart00349
    Location:158 → 218
    KRAB; krueppel associated box
    COG5048
    Location:746 → 933
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:833 → 853
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:705 → 730
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    6637318..6658279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446618.2 → XP_024302386.1  zinc finger protein 316 isoform X1

    UniProtKB/Swiss-Prot
    A6NFI3
    Conserved Domains (4) summary
    smart00349
    Location:158 → 218
    KRAB; krueppel associated box
    COG5048
    Location:746 → 933
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:833 → 853
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:705 → 730
    zf-H2C2_2; Zinc-finger double domain

  2. XM_024446619.2 → XP_024302387.1  zinc finger protein 316 isoform X1

    UniProtKB/Swiss-Prot
    A6NFI3
    Conserved Domains (4) summary
    smart00349
    Location:158 → 218
    KRAB; krueppel associated box
    COG5048
    Location:746 → 933
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:833 → 853
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:705 → 730
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6756509..6777459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356942.1 → XP_054212917.1  zinc finger protein 316 isoform X1

  2. XM_054356943.1 → XP_054212918.1  zinc finger protein 316 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NFI3.1 GenPept UniProtKB/Swiss-Prot:A6NFI3

Gene LinkOut

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