SPANXB2 SPANX family, member B2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPANXB2provided by HGNC
Official Full Name: SPANX family, member B2provided by HGNC
Primary source: HGNC:HGNC:14330
Gene type: protein coding
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPANX; SPANXB
Summary: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B1 and appears to be a duplication of that locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: Xq27.1

Annotation release	Status	Assembly	Chr	Location
105	latest, but not current	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (140084756..140085871)
105	latest, but not current	HuRef (GCF_000002125.1)	X	AC_000155.1 (129338398..129354824)
105	latest, but not current	CHM1_1.1 (GCF_000306695.2)	X	NC_018934.2 (139996314..139997457)

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Variation

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:481484

General protein information

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Names: SPANX family, member B2; CT11.2; SPAN-Xb protein; SPAN-Xf; SPANX family member B/F; SPANX family member B1; SPANX-B; SPANX-F; cancer/testis antigen 11.2; nuclear-associated protein SPAN-Xb; nuclear-associated protein SPAN-Xf; sperm protein associated with the nucleus on the X chromosome B/F; sperm protein associated with the nucleus, X chromosome, family member B2