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Akna AT-hook transcription factor [ Mus musculus (house mouse) ]

Gene ID: 100182, updated on 2-Nov-2024

Summary

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Official Symbol
Aknaprovided by MGI
Official Full Name
AT-hook transcription factorprovided by MGI
Primary source
MGI:MGI:2140340
See related
Ensembl:ENSMUSG00000039158 AllianceGenome:MGI:2140340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA binding activity. Involved in several processes, including epithelial to mesenchymal transition; neuroblast delamination; and neuroblast division in subventricular zone. Located in centriole; centrosome; and microtubule. Is expressed in genitourinary system; hemolymphoid system; nervous system; respiratory system; and sensory organ. Orthologous to human AKNA (AT-hook transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 37.5), thymus adult (RPKM 21.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Akna in Genome Data Viewer
Location:
4 B3; 4 33.96 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63285364..63328988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63367123..63411094, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene orosomucoid 3 Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor, opposite strand Neighboring gene predicted gene, 52742 Neighboring gene STARR-positive B cell enhancer ABC_E6185 Neighboring gene STARR-positive B cell enhancer ABC_E2692 Neighboring gene STARR-seq mESC enhancer starr_10437 Neighboring gene whirlin Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63141720-63141921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63150850-63151053 Neighboring gene STARR-positive B cell enhancer mm9_chr4:63205604-63205905 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 Neighboring gene predicted gene, 38592

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Ma W, et al. Cell Res, 2011 Nov. PMID 21606955, Free PMC Article
  2. The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, et al. Nature, 2019 Mar. PMID 30787442
  3. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death
    Title: Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC116630, mKIAA1968

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in delamination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epithelial to mesenchymal transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuroblast delamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuroblast delamination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuroblast division in subventricular zone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuroblast division in subventricular zone IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microtubule organization protein AKNA
Names
AT-hook-containing transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045514.4 → NP_001038979.1  microtubule organization protein AKNA isoform 1

    See identical proteins and their annotated locations for NP_001038979.1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    Consensus CDS
    CCDS38777.1
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    Related
    ENSMUSP00000041614.5, ENSMUST00000035724.5
    Conserved Domains (1) summary
    pfam12443
    Location:584 → 681
    AKNA; AT-hook-containing transcription factor

  2. NM_001305432.2 → NP_001292361.1  microtubule organization protein AKNA isoform 1

    See identical proteins and their annotated locations for NP_001292361.1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    Consensus CDS
    CCDS38777.1
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
    Conserved Domains (1) summary
    pfam12443
    Location:584 → 681
    AKNA; AT-hook-containing transcription factor

  3. NM_001426143.1 → NP_001413072.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

  4. NM_001426144.1 → NP_001413073.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

  5. NM_001426145.1 → NP_001413074.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

  6. NM_001426146.1 → NP_001413075.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

  7. NM_001426147.1 → NP_001413076.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

  8. NM_001426148.1 → NP_001413077.1  microtubule organization protein AKNA isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL683828
    UniProtKB/Swiss-Prot
    Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

  9. NM_001426149.1 → NP_001413078.1  microtubule organization protein AKNA isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683828

  10. NM_001426150.1 → NP_001413079.1  microtubule organization protein AKNA isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL683828

  11. NM_001426151.1 → NP_001413080.1  microtubule organization protein AKNA isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL683828

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63285364..63328988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163542.1 → XP_036019435.1  microtubule organization protein AKNA isoform X2

    Conserved Domains (1) summary
    pfam12443
    Location:584 → 681
    AKNA; AT-hook-containing transcription factor

  2. XM_036163544.1 → XP_036019437.1  microtubule organization protein AKNA isoform X3

    Conserved Domains (1) summary
    pfam12443
    Location:584 → 681
    AKNA; AT-hook-containing transcription factor

  3. XM_036163543.1 → XP_036019436.1  microtubule organization protein AKNA isoform X3

    Conserved Domains (1) summary
    pfam12443
    Location:584 → 681
    AKNA; AT-hook-containing transcription factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VW7.1 GenPept UniProtKB/Swiss-Prot:Q80VW7

Gene LinkOut

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