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Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate [ Rattus norvegicus (Norway rat) ]

Gene ID: 100270678, updated on 2-Nov-2024

Summary

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Official Symbol
Spns2provided by RGD
Official Full Name
SPNS lysolipid transporter 2, sphingosine-1-phosphateprovided by RGD
Primary source
RGD:2303312
See related
EnsemblRapid:ENSRNOG00000057040 AllianceGenome:RGD:2303312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable sphingolipid transporter activity and transmembrane transporter activity. Predicted to be involved in several processes, including regulation of T cell migration; sensory perception of sound; and sphingosine-1-phosphate receptor signaling pathway. Predicted to act upstream of or within several processes, including lymph node development; lymphocyte homeostasis; and regulation of eye pigmentation. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Orthologous to human SPNS2 (SPNS lysolipid transporter 2, sphingosine-1-phosphate). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 204.5), Kidney (RPKM 130.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spns2 in Genome Data Viewer
Location:
10q24
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (57565909..57604546, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (57067348..57105969, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (59010428..59049482, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene MYB binding protein 1a Neighboring gene gamma-glutamyl transferase 6 Neighboring gene SPNS lysolipid transporter 3, sphingosine-1-phosphate Neighboring gene uncharacterized LOC134480821 Neighboring gene ubiquitin-conjugating enzyme E2G 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis. Vanderhaeghen T, et al. EMBO Rep, 2023 Aug 3. PMID 37358010, Free PMC Article
  2. The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. Fukuhara S, et al. J Clin Invest, 2012 Apr. PMID 22406534, Free PMC Article
  3. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. Nijnik A, et al. J Immunol, 2012 Jul 1. PMID 22664872, Free PMC Article
  4. Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. Nagahashi M, et al. FASEB J, 2013 Mar. PMID 23180825, Free PMC Article
  5. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. Hisano Y, et al. J Biol Chem, 2011 Jan 21. PMID 21084291, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis.
    Title: Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sphingolipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingolipid transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymph node development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymphocyte homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of eye pigmentation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of humoral immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of humoral immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sphingosine-1-phosphate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingosine-1-phosphate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sphingosine-1-phosphate transporter SPNS2
Names
protein spinster homolog 2
sphingolipid transporter 2
spinster homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389255.1 → NP_001376184.1  sphingosine-1-phosphate transporter SPNS2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HGF8, A6HGG0
    Related
    ENSRNOP00000068809.2, ENSRNOT00000078272.3
    Conserved Domains (1) summary
    cd17328
    Location:106 → 520
    MFS_spinster_like; Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    57565909..57604546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010055110.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001144991.1: Suppressed sequence

    Description
    NM_001144991.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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