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ZNF783 zinc finger protein 783 [ Homo sapiens (human) ]

Gene ID: 100289678, updated on 8-Mar-2024

Summary

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Official Symbol
ZNF783provided by HGNC
Official Full Name
zinc finger protein 783provided by HGNC
Primary source
HGNC:HGNC:27222
See related
Ensembl:ENSG00000204946 AllianceGenome:HGNC:27222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 4.3), lymph node (RPKM 3.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF783 in Genome Data Viewer
Location:
7q36.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149262196..149284994)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150444011..150466766)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148959287..148982085)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148892414-148892735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148900065-148900565 Neighboring gene zinc finger protein 282 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:148906433-148907147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148916930-148917919 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148923698-148923905 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:148930294-148931493 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene zinc finger protein 212 Neighboring gene uncharacterized LOC124901769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148978524-148979060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18754 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148982524-148982701 Neighboring gene AI894139 pseudogene Neighboring gene tRNA-Cys (anticodon GCA) 1-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Gauci S, et al. Anal Chem, 2009 Jun 1. PMID 19413330
  2. Repression of rRNA transcription by PARIS contributes to Parkinson's disease. Kang H, et al. Neurobiol Dis, 2015 Jan. PMID 25315684
  3. Large-scale concatenation cDNA sequencing. Yu W, et al. Genome Res, 1997 Apr. PMID 9110174, Free PMC Article
  4. A "double adaptor" method for improved shotgun library construction. Andersson B, et al. Anal Biochem, 1996 Apr 5. PMID 8619474
  5. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12914, FLJ16713, DKFZp762P2111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 783
Names
protein ZNF783
zinc finger family member 783

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195220.2 → NP_001182149.1  zinc finger protein 783

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AC004890
    Consensus CDS
    CCDS56519.1
    UniProtKB/Swiss-Prot
    C9J9J2, Q6ZMS7
    Related
    ENSP00000410890.1, ENST00000434415.6
    Conserved Domains (8) summary
    cd07765
    Location:143 → 182
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:143 → 202
    KRAB; krueppel associated box
    COG5048
    Location:468 → 516
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:438 → 458
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:351 → 371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:468 → 488
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:57 → 112
    DUF3669; Zinc finger protein
    pfam13465
    Location:480 → 505
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_144366.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC004890

  2. NR_144367.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004890

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149262196..149284994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419692.1 → XP_047275648.1  zinc finger protein 783 isoform X2

  2. XM_011515701.3 → XP_011514003.1  zinc finger protein 783 isoform X1

    Conserved Domains (8) summary
    cd07765
    Location:154 → 193
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:154 → 213
    KRAB; krueppel associated box
    COG5048
    Location:479 → 527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449 → 469
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:479 → 499
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:68 → 123
    DUF3669; Zinc finger protein
    pfam13465
    Location:491 → 516
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001744503.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150444011..150466766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356965.1 → XP_054212940.1  zinc finger protein 783 isoform X2

  2. XM_054356964.1 → XP_054212939.1  zinc finger protein 783 isoform X1

RNA

  1. XR_008487516.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMS7.2 GenPept UniProtKB/Swiss-Prot:Q6ZMS7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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