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KIAA0319l KIAA0319 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 100294508, updated on 2-Nov-2024

Summary

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Official Symbol
KIAA0319lprovided by RGD
Official Full Name
KIAA0319 likeprovided by RGD
Primary source
RGD:2306719
See related
EnsemblRapid:ENSRNOG00000012204 AllianceGenome:RGD:2306719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in neuron migration. Predicted to act upstream of or within several processes, including flagellated sperm motility; proacrosomal vesicle fusion; and receptor-mediated endocytosis of virus by host cell. Predicted to be located in nucleolus and trans-Golgi network. Predicted to be active in Golgi apparatus; cytoplasmic vesicle; and membrane. Orthologous to human KIAA0319L (KIAA0319 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 190.9), Adrenal (RPKM 173.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See KIAA0319l in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (144332242..144425182)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (139047847..139140709)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144779306..144872271)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transcription factor AP-2 epsilon Neighboring gene neurochondrin Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486992 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene zinc finger MYM-type containing 4 Neighboring gene ribosomal protein L35A, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. AU040320 deficiency leads to disruption of acrosome biogenesis and infertility in homozygous mutant mice. Guidi LG, et al. Sci Rep, 2018 Jul 10. PMID 29991750, Free PMC Article
  2. An essential receptor for adeno-associated virus infection. Pillay S, et al. Nature, 2016 Feb 4. PMID 26814968, Free PMC Article
  3. Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. Poon MW, et al. Cell Mol Neurobiol, 2011 Jan. PMID 20697954
  4. Knockout Mice for Dyslexia Susceptibility Gene Homologs KIAA0319 and KIAA0319L have Unaffected Neuronal Migration but Display Abnormal Auditory Processing. Guidi LG, et al. Cereb Cortex, 2017 Dec 1. PMID 29045729, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within acrosome assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proacrosomal vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within receptor-mediated endocytosis of virus by host cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to auditory stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dyslexia-associated protein KIAA0319-like protein homolog
Names
dyslexia susceptibility 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159655.4 → NP_001153127.1  dyslexia-associated protein KIAA0319-like protein homolog

    See identical proteins and their annotated locations for NP_001153127.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6ISB7
    Related
    ENSRNOP00000016493.7, ENSRNOT00000016493.8
    Conserved Domains (4) summary
    smart00089
    Location:409 → 495
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    pfam02010
    Location:629 → 807
    REJ; REJ domain
    pfam07974
    Location:891 → 911
    EGF_2; EGF-like domain
    pfam18911
    Location:583 → 672
    PKD_4; PKD domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    144332242..144425182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287023.1 → XP_063143093.1  dyslexia-associated protein KIAA0319-like protein homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6APE1
    Related
    ENSRNOP00000096491.1, ENSRNOT00000119747.2

  2. XM_063287024.1 → XP_063143094.1  dyslexia-associated protein KIAA0319-like protein homolog isoform X2

    UniProtKB/TrEMBL
    F1M4J1
    Related
    ENSRNOP00000093082.1, ENSRNOT00000100704.2

  3. XM_063287025.1 → XP_063143095.1  dyslexia-associated protein KIAA0319-like protein homolog isoform X2

    UniProtKB/TrEMBL
    F1M4J1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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