U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MIR1254-1 microRNA 1254-1 [ Homo sapiens (human) ]

Gene ID: 100302273, discontinued on 14-Mar-2018
  • This record was discontinued.

Summary

Go to the top of the page Help
Official Symbol
MIR1254-1provided by HGNC
Official Full Name
microRNA 1254-1provided by HGNC
Primary source
HGNC:HGNC:35319
See related
miRBase:MI0006388
Gene type
ncRNA
RefSeq status
WITHDRAWN
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIR1254; MIRN1254; hsa-mir-1254; hsa-mir-1254-1
Summary
This record was withdrawn by miRBase.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q21.3
Exon count:
1
Annotation release Status Assembly Chr Location
105 latest, but not current GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (70519075..70519171)
105 latest, but not current HuRef (GCF_000002125.1) 10 AC_000142.1 (64520460..64520556)
105 latest, but not current CHM1_1.1 (GCF_000306695.2) 10 NC_018921.2 (70802511..70802607)

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000010.11 Chromosome 10 Reference GRCh38.p12 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-1254 is markedly upregulated in human breast cancer tissues. miR-1254 potently promotes breast cancer cell growth and cycle transition. RASSF9 is a direct target of miR-1254.
    Title: MicroRNA-1254 exerts oncogenic effects by directly targeting RASSF9 in human breast cancer.
  2. miR-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.
    Title: miR-1254 promotes lung cancer cell proliferation by targeting SFRP1.
  3. MicroRNA-1254 may act as a tumor suppressor and inhibits the migration of colon adenocarcinoma cells by targeting PSMD10.
    Title: MicroRNA-1254 inhibits the migration of colon adenocarcinoma cells by targeting PSMD10.
  4. We identified miR-1254 as a negative regulator inhibiting HO-1 translation by directly targeting HO-1 3'UTR via its seed region, and suppressing HO-1 transcription via non-seed region-dependent inhibition of transcriptional factor AP-2 alpha (TFAP2A), a transcriptional activator of HO-1.
    Title: MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth.
  5. High serum microRNA 1254 expression is associated with early-stage non-small cell lung cancer.
    Title: miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Markers

Other Names

  • microRNA 1254

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 (NOTE: not current)

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    68759318..68759414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_031655.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.