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Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked [ Rattus norvegicus (Norway rat) ]

Gene ID: 100310845, updated on 10-Oct-2024

Summary

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Symbol
Utyprovided by RGD
Full Name
ubiquitously transcribed tetratricopeptide repeat containing, Y-linkedprovided by RGD
Primary source
RGD:1565481
See related
EnsemblRapid:ENSRNOG00000060617 AllianceGenome:RGD:1565481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Utx; Kdm6a; RGD1565481
Summary
Enables chromatin binding activity. Predicted to act upstream of or within several processes, including animal organ development; cardiac muscle cell contraction; and heterochromatin assembly. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 124.7), Spleen (RPKM 99.9) and 8 other tissues See more
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Genomic context

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See Uty in Genome Data Viewer
Location:
Yq11
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) Y NC_086040.1 (1018111..1178493, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) Y NC_051357.1 (942838..1105313, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) Y NC_024475.1 (1065274..1206127, complement)

Chromosome Y - NC_086040.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-like modifier-activating enzyme 1 Y Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Neighboring gene ubiquitin-conjugating enzyme E2 Q2 pseudogene Neighboring gene DEAD box helicase 3, Y-linked Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin specific peptidase 9, Y-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia. Mar BG, et al. Leukemia, 2012 Aug. PMID 22377896, Free PMC Article
  2. Expression and significance of histone H3K27 demethylases in renal cell carcinoma. Shen Y, et al. BMC Cancer, 2012 Oct 12. PMID 23057811, Free PMC Article
  3. Genetic landscape of esophageal squamous cell carcinoma. Gao YB, et al. Nat Genet, 2014 Oct. PMID 25151357
  4. Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes. Komers R, et al. Lab Invest, 2013 May. PMID 23508046
  5. SWI/SNF nucleosome remodellers and cancer. Wilson BG, et al. Nat Rev Cancer, 2011 Jun 9. PMID 21654818

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 demethylase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysine-specific demethylase 6A
Names
histone demethylase UTY
histone demethylase UTY-like
lysine (K)-specific demethylase 6A
lysine demethylase 6A
ubiquitously transcribed tetratricopeptide repeat gene, X chromosome
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
ubiquitously transcribed tetratricopeptide repeat, X chromosome
NP_001406760.1
NP_001406761.1
XP_008771917.2
XP_017457936.3
XP_038956599.1
XP_038956600.1
XP_038956601.1
XP_038956603.1
XP_038956604.1
XP_038956605.1
XP_038956606.1
XP_038956607.1
XP_038956608.1
XP_038956611.1
XP_038956612.1
XP_063136645.1
XP_063136646.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419831.1 → NP_001406760.1  lysine-specific demethylase 6A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000022
    Related
    ENSRNOP00000104952.1, ENSRNOT00000149304.1

  2. NM_001419832.1 → NP_001406761.1  lysine-specific demethylase 6A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000022
    Related
    ENSRNOP00000097587.2, ENSRNOT00000119067.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086040.1 Reference GRCr8

    Range
    1018111..1178493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100676.2 → XP_038956604.1  lysine-specific demethylase 6A isoform X8

    UniProtKB/TrEMBL
    A0A8I6G9K0
    Conserved Domains (5) summary
    smart00028
    Location:140 → 173
    TPR; Tetratricopeptide repeats
    smart00558
    Location:905 → 969
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:175 → 410
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:317 → 344
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:939 → 1047
    JmjC; JmjC domain, hydroxylase

  2. XM_039100671.2 → XP_038956599.1  lysine-specific demethylase 6A isoform X2

    UniProtKB/TrEMBL
    A0A8I6GMK8
    Conserved Domains (4) summary
    smart00558
    Location:949 → 1013
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:174 → 409
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:316 → 343
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:983 → 1091
    JmjC; JmjC domain, hydroxylase

  3. XM_039100673.2 → XP_038956601.1  lysine-specific demethylase 6A isoform X4

    UniProtKB/TrEMBL
    A0A8I6GMK8
    Conserved Domains (5) summary
    smart00028
    Location:121 → 154
    TPR; Tetratricopeptide repeats
    smart00558
    Location:931 → 995
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:156 → 391
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:298 → 325
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:965 → 1073
    JmjC; JmjC domain, hydroxylase

  4. XM_008773695.4 → XP_008771917.2  lysine-specific demethylase 6A isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMK8
    Conserved Domains (5) summary
    smart00028
    Location:140 → 173
    TPR; Tetratricopeptide repeats
    smart00558
    Location:950 → 1014
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:175 → 410
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:317 → 344
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:984 → 1092
    JmjC; JmjC domain, hydroxylase

  5. XM_039100672.2 → XP_038956600.1  lysine-specific demethylase 6A isoform X3

    UniProtKB/TrEMBL
    A0A8I6GMK8
    Conserved Domains (5) summary
    smart00558
    Location:935 → 999
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:41 → 332
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    COG4235
    Location:286 → 388
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:302 → 329
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:969 → 1077
    JmjC; JmjC domain, hydroxylase

  6. XM_039100677.2 → XP_038956605.1  lysine-specific demethylase 6A isoform X9

    UniProtKB/TrEMBL
    A0A8I6G9K0
    Conserved Domains (4) summary
    smart00558
    Location:883 → 947
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:119 → 388
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:295 → 322
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:917 → 1025
    JmjC; JmjC domain, hydroxylase

  7. XM_039100678.2 → XP_038956606.1  lysine-specific demethylase 6A isoform X10

    UniProtKB/TrEMBL
    A0A8I6G9K0
    Conserved Domains (4) summary
    smart00558
    Location:868 → 932
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:101 → 373
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:280 → 307
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:902 → 1010
    JmjC; JmjC domain, hydroxylase

  8. XM_039100675.2 → XP_038956603.1  lysine-specific demethylase 6A isoform X5

    UniProtKB/TrEMBL
    A0A8I6GMK8
    Related
    ENSRNOP00000082524.2, ENSRNOT00000093013.3
    Conserved Domains (4) summary
    smart00558
    Location:928 → 992
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:119 → 388
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:295 → 322
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:962 → 1070
    JmjC; JmjC domain, hydroxylase

  9. XM_017602447.3 → XP_017457936.3  lysine-specific demethylase 6A isoform X7

  10. XM_039100679.2 → XP_038956607.1  lysine-specific demethylase 6A isoform X11

    UniProtKB/TrEMBL
    W8C8I9
    Conserved Domains (5) summary
    smart00028
    Location:32 → 65
    TPR; Tetratricopeptide repeats
    smart00558
    Location:842 → 906
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:67 → 302
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:209 → 236
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:876 → 984
    JmjC; JmjC domain, hydroxylase

  11. XM_063280576.1 → XP_063136646.1  lysine-specific demethylase 6A isoform X13

  12. XM_039100680.2 → XP_038956608.1  lysine-specific demethylase 6A isoform X12

    UniProtKB/TrEMBL
    W8C8I9
    Conserved Domains (4) summary
    smart00558
    Location:744 → 808
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:56 → 204
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:111 → 138
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:778 → 886
    JmjC; JmjC domain, hydroxylase

  13. XM_039100683.2 → XP_038956611.1  lysine-specific demethylase 6A isoform X14

    UniProtKB/TrEMBL
    W8C8I9
    Conserved Domains (4) summary
    smart00558
    Location:667 → 731
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:18 → 127
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:34 → 61
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:701 → 809
    JmjC; JmjC domain, hydroxylase

  14. XM_039100684.2 → XP_038956612.1  lysine-specific demethylase 6A isoform X15

    UniProtKB/TrEMBL
    W8C8I9
    Conserved Domains (4) summary
    smart00558
    Location:646 → 710
    JmjC; A domain family that is part of the cupin metalloenzyme superfamily
    COG0457
    Location:22 → 106
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:45 → 75
    TPR; TPR repeat [structural motif]
    pfam02373
    Location:680 → 788
    JmjC; JmjC domain, hydroxylase

  15. XM_063280575.1 → XP_063136645.1  lysine-specific demethylase 6A isoform X6

    Related
    ENSRNOP00000082150.2, ENSRNOT00000082648.3

RNA

  1. XR_005498739.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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