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Parpbp PARP1 binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 100310874, updated on 28-Oct-2024

Summary

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Official Symbol
Parpbpprovided by RGD
Official Full Name
PARP1 binding proteinprovided by RGD
Primary source
RGD:2314264
See related
EnsemblRapid:ENSRNOG00000004682 AllianceGenome:RGD:2314264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AROM; PARI
Summary
Predicted to enable DNA binding activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination. Predicted to be located in chromatin and nucleoplasm. Orthologous to human PARPBP (PARP1 binding protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Testes (RPKM 33.7), Thymus (RPKM 33.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Parpbp in Genome Data Viewer
Location:
7q13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24398897..24468330, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22511427..22580834, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28654707..28724412, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma, pseudogene 6 Neighboring gene pro-melanin-concentrating hormone Neighboring gene nucleoporin 37 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC120093767

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The AROM gene, spliced mRNAs encoding new DNA/RNA-binding proteins are transcribed from the opposite strand of the melanin-concentrating hormone gene in mammals. Borsu L, et al. J Biol Chem, 2000 Dec 22. PMID 11006283
  2. Inhibition of homologous recombination by the PCNA-interacting protein PARI. Moldovan GL, et al. Mol Cell, 2012 Jan 13. PMID 22153967, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PCNA-interacting partner
Names
PARP-1 binding protein
antisense RNA overlapping MCH gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166676.2 → NP_001160148.1  PCNA-interacting partner isoform 3

    See identical proteins and their annotated locations for NP_001160148.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6IFN2
    Related
    ENSRNOP00000060859.1, ENSRNOT00000065899.5
    Conserved Domains (1) summary
    TIGR01075
    Location:92 → 243
    uvrD; DNA helicase II

  2. NM_001401236.1 → NP_001388165.1  PCNA-interacting partner isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A0H2UHD2, A6IFN1

  3. NM_001401237.1 → NP_001388166.1  PCNA-interacting partner isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q9EQ10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    24398897..24468330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262830.1 → XP_063118900.1  PCNA-interacting partner isoform X4

    UniProtKB/TrEMBL
    A0A0H2UHD2, A6IFN1
    Related
    ENSRNOP00000006249.5, ENSRNOT00000006249.7

  2. XM_006241189.5 → XP_006241251.1  PCNA-interacting partner isoform X3

    See identical proteins and their annotated locations for XP_006241251.1

    UniProtKB/Swiss-Prot
    Q9EQ10
    UniProtKB/TrEMBL
    A6IFN0
    Conserved Domains (1) summary
    TIGR01075
    Location:173 → 324
    uvrD; DNA helicase II

  3. XM_039078223.2 → XP_038934151.1  PCNA-interacting partner isoform X2

    UniProtKB/TrEMBL
    G3V6L0
    Related
    ENSRNOP00000006174.2, ENSRNOT00000006174.5
    Conserved Domains (1) summary
    PRK10919
    Location:228 → 372
    PRK10919; ATP-dependent DNA helicase Rep; Provisional

  4. XM_039078222.2 → XP_038934150.1  PCNA-interacting partner isoform X1

    Conserved Domains (1) summary
    PRK10919
    Location:228 → 372
    PRK10919; ATP-dependent DNA helicase Rep; Provisional

  5. XM_063262831.1 → XP_063118901.1  PCNA-interacting partner isoform X5

  6. XM_063262832.1 → XP_063118902.1  PCNA-interacting partner isoform X5

  7. XM_039078224.2 → XP_038934152.1  PCNA-interacting partner isoform X6

    Conserved Domains (1) summary
    PRK10919
    Location:228 → 295
    PRK10919; ATP-dependent DNA helicase Rep; Provisional

  8. XM_063262833.1 → XP_063118903.1  PCNA-interacting partner isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQ10.2 GenPept UniProtKB/Swiss-Prot:Q9EQ10

Gene LinkOut

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