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Palm3 paralemmin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100359592, updated on 10-Oct-2024

Summary

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Official Symbol
Palm3provided by RGD
Official Full Name
paralemmin 3provided by RGD
Primary source
RGD:2323602
See related
EnsemblRapid:ENSRNOG00000005729 AllianceGenome:RGD:2323602
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Orthologous to human PALM3 (paralemmin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 34.9), Brain (RPKM 5.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Palm3 in Genome Data Viewer
Location:
19q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41026757..41035217, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24121984..24126079, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25143464..25152275)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene relaxin 3 Neighboring gene interleukin 27 receptor subunit alpha Neighboring gene MISP family member 3 Neighboring gene microRNA 1199 Neighboring gene similar to human chromosome 19 open reading frame 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages. Chen XX, et al. Int J Mol Med, 2017 Dec. PMID 29039447
  2. A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3. Chen X, et al. Biochem Biophys Res Commun, 2011 Jan 28. PMID 21187075
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paralemmin-3 augments lipopolysaccharide-induced acute lung injury with M1 macrophage polarization via the notch signaling pathway.
    Title: Paralemmin-3 augments lipopolysaccharide-induced acute lung injury with M1 macrophage polarization via the notch signaling pathway.
  2. These results suggested that PALM3 contributes to the LPS-induced inflammatory response and participates in LPS-TLR4 signaling in Alveolar macrophages . These data may provide the basis for the development of novel targeted therapeutic strategies of treating acute lung injury.
    Title: Paralemmin-3 contributes to lipopolysaccharide-induced inflammatory response and is involved in lipopolysaccharide-Toll-like receptor-4 signaling in alveolar macrophages.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Toll signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
paralemmin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    41026757..41035217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002728582.7 → XP_002728628.3  paralemmin-3

    UniProtKB/TrEMBL
    A6IYB5, D4A1J3
    Related
    ENSRNOP00000007535.5, ENSRNOT00000007535.8
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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