U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnaaf3 dynein, axonemal, assembly factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100359753, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Dnaaf3provided by RGD
Official Full Name
dynein, axonemal, assembly factor 3provided by RGD
Primary source
RGD:2323487
See related
EnsemblRapid:ENSRNOG00000038600 AllianceGenome:RGD:2323487
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in axonemal dynein complex assembly and motile cilium assembly. Predicted to act upstream of or within determination of left/right symmetry and heart development. Predicted to be located in dynein axonemal particle. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 2. Orthologous to human DNAAF3 (dynein axonemal assembly factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 380.0), Testes (RPKM 32.8) and 1 other tissue See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dnaaf3 in Genome Data Viewer
Location:
1q12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (78333985..78342034)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (69291300..69299365)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (72874131..72882867)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, H Neighboring gene uncharacterized LOC108349515 Neighboring gene synaptotagmin 5 Neighboring gene troponin I3, cardiac type Neighboring gene troponin T1, slow skeletal type

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia. Mitchison HM, et al. Nat Genet, 2012 Mar 4. PMID 22387996, Free PMC Article
  2. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
  3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  4. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonemal dynein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in axonemal dynein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in axonemal dynein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in motile cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in dynein axonemal particle IEA
Inferred from Electronic Annotation
more info
  
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dynein axonemal assembly factor 3
Names
Dynein assembly factor 3, axonemal

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271115.1 → NP_001258044.1  dynein axonemal assembly factor 3

    See identical proteins and their annotated locations for NP_001258044.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    D3ZCM9
    Conserved Domains (3) summary
    PTZ00436
    Location:463 → 579
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    pfam14737
    Location:16 → 122
    DUF4470; Domain of unknown function (DUF4470)
    pfam14740
    Location:154 → 434
    DUF4471; Domain of unknown function (DUF4471)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    78333985..78342034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588635.3 → XP_017444124.1  dynein axonemal assembly factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QR42
    Related
    ENSRNOP00000055687.4, ENSRNOT00000058900.6

  2. XM_039101466.2 → XP_038957394.1  dynein axonemal assembly factor 3 isoform X1

    Conserved Domains (3) summary
    PTZ00436
    Location:533 → 657
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    pfam14737
    Location:60 → 187
    DUF4470; Domain of unknown function (DUF4470)
    pfam14740
    Location:219 → 499
    DUF4471; Domain of unknown function (DUF4471)

  3. XM_039101524.2 → XP_038957452.1  dynein axonemal assembly factor 3 isoform X3

    Conserved Domains (3) summary
    PTZ00436
    Location:489 → 611
    PTZ00436; 60S ribosomal protein L19-like protein; Provisional
    pfam14737
    Location:16 → 143
    DUF4470; Domain of unknown function (DUF4470)
    pfam14740
    Location:175 → 455
    DUF4471; Domain of unknown function (DUF4471)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZCM9.1 GenPept UniProtKB/Swiss-Prot:D3ZCM9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools