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LOC100359876 multifunctional protein ADE2-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 100359876, updated on 2-Nov-2024

Summary

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Symbol
LOC100359876provided by RGD
Full Name
multifunctional protein ADE2-likeprovided by RGD
Primary source
RGD:2323267
See related
AllianceGenome:RGD:2323267
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AABR07036855.1
Summary
Predicted to enable ATP binding activity and phosphoribosylaminoimidazole carboxylase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 612.2), Kidney (RPKM 595.7) and 9 other tissues See more
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Genomic context

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See LOC100359876 in Genome Data Viewer
Location:
Xq11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (6635011..6636484)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (4032827..4034310)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (4285780..4287222)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene protein FAM156A/FAM156B-like Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 19 Neighboring gene uncharacterized LOC108349162 Neighboring gene divergent protein kinase domain 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazole carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    6635011..6636484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100238.2 → XP_038956166.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase-like

    UniProtKB/TrEMBL
    A0A0G2K5S4, A6JCW6, A6JZV0
    Conserved Domains (2) summary
    cd01416
    Location:1 → 166
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:176 → 329
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein
Nucleotide Protein Strain
Heading Accession and Version

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