U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Palld palladin, cytoskeletal associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360205, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Symbol
Palldprovided by RGD
Full Name
palladin, cytoskeletal associated proteinprovided by RGD
Primary source
RGD:2322545
See related
EnsemblRapid:ENSRNOG00000010107 AllianceGenome:RGD:2322545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Palldl1; AABR07025295.1
Summary
Enables cytoskeletal protein binding activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of podosome assembly; and trophoblast giant cell differentiation. Located in several cellular components, including Z disc; actin cytoskeleton; and axonal growth cone. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 195.1), Heart (RPKM 175.2) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Palld in Genome Data Viewer
Location:
16p12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (33238943..33632236)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28228006..28621349)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (31865712..31948168)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482494 Neighboring gene DEXD/H-box helicase 60 Neighboring gene uncharacterized LOC120097508 Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482542 Neighboring gene carbonyl reductase 4 Neighboring gene SH3 domain containing ring finger 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Palladin is expressed preferentially in excitatory terminals in the rat central nervous system. Hwang SJ, et al. J Comp Neurol, 2001 Jul 23. PMID 11438925
  2. A role for the cytoskeleton-associated protein palladin in neurite outgrowth. Boukhelifa M, et al. Mol Biol Cell, 2001 Sep. PMID 11553711, Free PMC Article
  3. A critical role for palladin in astrocyte morphology and response to injury. Boukhelifa M, et al. Mol Cell Neurosci, 2003 Aug. PMID 12932445
  4. Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. Salaria SN, et al. Cancer Biol Ther, 2007 Mar. PMID 17404500, Free PMC Article
  5. Angiotensin II, focal adhesion kinase, and PRX1 enhance smooth muscle expression of lipoma preferred partner and its newly identified binding partner palladin to promote cell migration. Jin L, et al. Circ Res, 2007 Mar 30. PMID 17322171

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
    Title: [High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in epithelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within epithelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in keratinocyte development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within keratinocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of podosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ruffle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trophoblast giant cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin filament IEA
Inferred from Electronic Annotation
more info
  
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in excitatory synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
palladin; palladin, cytoskeletal associated protein
Names
palladin-like
palladin-like 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433250.1 → NP_001420179.1  palladin, cytoskeletal associated protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  2. NM_001433251.1 → NP_001420180.1  palladin, cytoskeletal associated protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZQM3

  3. NM_001433252.1 → NP_001420181.1  palladin, cytoskeletal associated protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6A9U3

  4. NM_001433253.1 → NP_001420182.1  palladin, cytoskeletal associated protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  5. NM_001433254.1 → NP_001420183.1  palladin, cytoskeletal associated protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    33238943..33632236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094916.2 → XP_038950844.1  palladin isoform X3

    Related
    ENSRNOP00000080820.2, ENSRNOT00000095888.2
    Conserved Domains (6) summary
    pfam07679
    Location:449 → 546
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:1161 → 1164
    Ig; Ig strand A [structural motif]
    cd05892
    Location:1260 → 1351
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:1027 → 1118
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cd20972
    Location:278 → 369
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:1161 → 1251
    Ig; Immunoglobulin domain

  2. XM_039094914.2 → XP_038950842.1  palladin isoform X1

    Related
    ENSRNOP00000091553.2, ENSRNOT00000111769.2
    Conserved Domains (6) summary
    pfam07679
    Location:449 → 546
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:1161 → 1164
    Ig; Ig strand A [structural motif]
    cd05892
    Location:1260 → 1351
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:1027 → 1118
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cd20972
    Location:278 → 369
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:1161 → 1251
    Ig; Immunoglobulin domain

  3. XM_039094915.2 → XP_038950843.1  palladin isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADH4
    Conserved Domains (6) summary
    pfam07679
    Location:449 → 546
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:1144 → 1147
    Ig; Ig strand A [structural motif]
    cd05892
    Location:1243 → 1334
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:1010 → 1101
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cd20972
    Location:278 → 369
    IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains
    cl11960
    Location:1144 → 1234
    Ig; Immunoglobulin domain

  4. XM_039094917.2 → XP_038950845.1  palladin isoform X4

    UniProtKB/TrEMBL
    F1M265
    Conserved Domains (5) summary
    pfam07679
    Location:59 → 156
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:771 → 774
    Ig; Ig strand A [structural motif]
    cd05892
    Location:870 → 961
    IgI_Myotilin_C; C-terminal immunoglobulin (Ig)-like domain of myotilin; member of the I-set of Ig superfamily (IgSF) domains
    cd05893
    Location:637 → 728
    IgI_1_Palladin_C; First C-terminal immunoglobulin (Ig)-like domain of palladin; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:771 → 861
    Ig; Immunoglobulin domain

  5. XM_008771231.4 → XP_008769453.1  palladin isoform X5

    Conserved Domains (3) summary
    cd00096
    Location:315 → 384
    Ig; Immunoglobulin domain
    cd05893
    Location:548 → 622
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:432 → 522
    I-set; Immunoglobulin I-set domain

  6. XM_008771232.4 → XP_008769454.1  palladin isoform X6

    Related
    ENSRNOP00000088354.1, ENSRNOT00000116705.2
    Conserved Domains (3) summary
    cd00096
    Location:298 → 367
    Ig; Immunoglobulin domain
    cd05893
    Location:531 → 605
    Ig_Palladin_C; C-terminal immunoglobulin (Ig)-like domain of palladin
    pfam07679
    Location:415 → 505
    I-set; Immunoglobulin I-set domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.