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Lyset lysosomal enzyme trafficking factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360358, updated on 17-Aug-2024

Summary

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Official Symbol
Lysetprovided by RGD
Official Full Name
lysosomal enzyme trafficking factorprovided by RGD
Primary source
RGD:1566396
See related
EnsemblRapid:ENSRNOG00000008101 AllianceGenome:RGD:1566396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tmem251; RGD1566396
Summary
Predicted to be integral component of membrane. Orthologous to human TMEM251 (transmembrane protein 251). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 60.8), Kidney (RPKM 53.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lyset in Genome Data Viewer
Location:
6q32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (127649401..127651143)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (121884577..121886319)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (126622692..126630642)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548370 Neighboring gene modulator of apoptosis 1 Neighboring gene GON7 subunit of KEOPS complex Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene nuclear nucleic acid-binding protein C1D-like Neighboring gene BTB domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway. Zhang W, et al. Nat Commun, 2022 Sep 12. PMID 36096887, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in lysosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lysosomal enzyme trafficking factor
Names
transmembrane protein 251

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398552.1 → NP_001385481.1  lysosomal enzyme trafficking factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    F1LXS7
    Related
    ENSRNOP00000010672.5, ENSRNOT00000010672.8
    Conserved Domains (1) summary
    pfam15190
    Location:34 → 161
    TMEM251; Transmembrane protein 251

  2. NM_001398553.1 → NP_001385482.1  lysosomal enzyme trafficking factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    Conserved Domains (1) summary
    pfam15190
    Location:2 → 129
    TMEM251; Transmembrane protein 251

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    127649401..127651143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LXS7.2 GenPept UniProtKB/Swiss-Prot:F1LXS7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials