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Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360412, updated on 2-Nov-2024

Summary

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Official Symbol
Dnajc1provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C1provided by RGD
Primary source
RGD:2322144
See related
EnsemblRapid:ENSRNOG00000000150 AllianceGenome:RGD:2322144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in regulation of protein secretion. Predicted to act upstream of or within protein folding and regulation of translation. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in endomembrane system. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 129.9), Spleen (RPKM 105.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajc1 in Genome Data Viewer
Location:
17q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (85863651..86020954, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (80955209..81112025, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (84986994..85141464, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108353137 Neighboring gene SKI/DACH domain containing 1 Neighboring gene MLLT10, histone lysine methyltransferase DOT1L cofactor Neighboring gene uncharacterized LOC108348596 Neighboring gene uncharacterized LOC134482756 Neighboring gene uncharacterized LOC134482757 Neighboring gene ATP-dependent RNA helicase DDX39A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity. Kroczynska B, et al. J Biol Chem, 2004 Mar 19. PMID 14668352, Free PMC Article
  2. Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Nakatsuka A, et al. Diabetes, 2012 Nov. PMID 22837305, Free PMC Article
  3. A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. Dudek J, et al. EMBO J, 2002 Jun 17. PMID 12065409, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 1
Names
DnaJ (Hsp40) homolog, subfamily C, member 1
DnaJ (Hsp40) homolog, subfamily C, member 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400837.1 → NP_001387766.1  dnaJ homolog subfamily C member 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6JM90, F1LVX1
    Related
    ENSRNOP00000000162.7, ENSRNOT00000000162.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    85863651..86020954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096460.2 → XP_038952388.1  dnaJ homolog subfamily C member 1 isoform X2

    Conserved Domains (1) summary
    cd00167
    Location:269 → 316
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. XM_039096459.2 → XP_038952387.1  dnaJ homolog subfamily C member 1 isoform X1

    Conserved Domains (1) summary
    pfam00226
    Location:72 → 133
    DnaJ; DnaJ domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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