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Ddx60 DEXD/H-box helicase 60 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100360801, updated on 10-Oct-2024

Summary

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Symbol
Ddx60provided by RGD
Full Name
DEXD/H-box helicase 60provided by RGD
Primary source
RGD:1560014
See related
EnsemblRapid:ENSRNOG00000059097 AllianceGenome:RGD:1560014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560014; AABR07025140.1
Expression
Biased expression in Spleen (RPKM 282.6), Lung (RPKM 203.1) and 8 other tissues See more
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Genomic context

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See Ddx60 in Genome Data Viewer
Location:
16p12
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (33087940..33208843, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28077000..28197903, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (29816144..29936220, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene probable ATP-dependent RNA helicase DDX60 Neighboring gene uncharacterized LOC134482493 Neighboring gene palladin-like 1 Neighboring gene uncharacterized LOC134482494 Neighboring gene uncharacterized LOC120097508 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. Miyashita M, et al. Mol Cell Biol, 2011 Sep. PMID 21791617, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DEXD/H-box helicase 60
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
mCG11385-like
probable ATP-dependent RNA helicase DDX60
probable ATP-dependent RNA helicase DDX60-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419856.1 → NP_001406785.1  DEXD/H-box helicase 60

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Related
    ENSRNOP00000074057.3, ENSRNOT00000088707.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    33087940..33208843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274962.1 → XP_063131032.1  DEXD/H-box helicase 60 isoform X3

  2. XM_063274961.1 → XP_063131031.1  DEXD/H-box helicase 60 isoform X2

  3. XM_063274958.1 → XP_063131028.1  DEXD/H-box helicase 60 isoform X1

  4. XM_063274959.1 → XP_063131029.1  DEXD/H-box helicase 60 isoform X1

  5. XM_063274957.1 → XP_063131027.1  DEXD/H-box helicase 60 isoform X1

  6. XM_063274960.1 → XP_063131030.1  DEXD/H-box helicase 60 isoform X1

  7. XM_039095171.2 → XP_038951099.1  DEXD/H-box helicase 60 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K744
    Conserved Domains (2) summary
    COG4581
    Location:759 → 1369
    Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    cd18025
    Location:760 → 937
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

  8. XM_039095173.2 → XP_038951101.1  DEXD/H-box helicase 60 isoform X5

    Conserved Domains (1) summary
    cd18025
    Location:760 → 937
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

  9. XM_039095174.2 → XP_038951102.1  DEXD/H-box helicase 60 isoform X6

    Conserved Domains (1) summary
    cd18025
    Location:760 → 937
    DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials