Lamtor1l1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lamtor1l1provided by RGD
Official Full Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1provided by RGD
Primary source: RGD:2319924
See related: Ensembl:ENSRNOG00000004319 AllianceGenome:RGD:2319924
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AABR07038019.1
Summary: Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cholesterol homeostasis; positive regulation of intracellular signal transduction; and regulation of cholesterol transport. Located in late endosome membrane and membrane raft. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: Xq14

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (38446140..38447189)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (34637460..34638509)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (37261428..37262470)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosomal transport	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in lysosome organization	IEA Inferred from Electronic Annotation more info
involved_in lysosome organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cholesterol import	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in regulation of receptor recycling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Ragulator complex	IEA Inferred from Electronic Annotation more info
part_of Ragulator complex	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1

Names: RhoA activator C11orf59-like; ragulator complex protein LAMTOR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409102.1 → NP_001396031.1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1

Status: INFERRED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6P791

UniProtKB/TrEMBL

A0A8L2QET1, A6I6Y5

Related

ENSRNOP00000089922.1, ENSRNOT00000005702.3