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Ano2 anoctamin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100361584, updated on 2-Nov-2024

Summary

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Official Symbol
Ano2provided by RGD
Official Full Name
anoctamin 2provided by RGD
Primary source
RGD:1591606
See related
EnsemblRapid:ENSRNOG00000023561 AllianceGenome:RGD:1591606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to act upstream of or within chloride transport and establishment of localization in cell. Predicted to be located in neuron projection; non-motile cilium; and nucleoplasm. Predicted to be active in glutamatergic synapse and presynaptic membrane. Orthologous to human ANO2 (anoctamin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 7.8), Lung (RPKM 7.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ano2 in Genome Data Viewer
Location:
4q42
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (160200471..160541830)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (158514200..158855639)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (158222650..158577595)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486684 Neighboring gene von Willebrand factor Neighboring gene uncharacterized LOC134486685 Neighboring gene U6 spliceosomal RNA Neighboring gene neurotrophin 3 Neighboring gene uncharacterized LOC102546745 Neighboring gene uncharacterized LOC134486842

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Targeted expression of anoctamin calcium-activated chloride channels in rod photoreceptor terminals of the rodent retina. Dauner K, et al. Invest Ophthalmol Vis Sci, 2013 May 3. PMID 23557741
  2. TMEM16A and TMEM16B channel proteins generate Ca(2+)-activated Cl(-) current and regulate melatonin secretion in rat pineal glands. Yamamura H, et al. J Biol Chem, 2018 Jan 19. PMID 29187602, Free PMC Article
  3. Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels. Vocke K, et al. J Gen Physiol, 2013 Oct. PMID 24081981, Free PMC Article
  4. TMEM16B induces chloride currents activated by calcium in mammalian cells. Pifferi S, et al. Pflugers Arch, 2009 Oct. PMID 19475416
  5. ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Stephan AB, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19561302, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM16A and TMEM16B channel proteins generate Ca(2+)-activated Cl(-) current and regulate melatonin secretion in rat pineal glands.
    Title: TMEM16A and TMEM16B channel proteins generate Ca(2+)-activated Cl(-) current and regulate melatonin secretion in rat pineal glands.
  2. Rod photoreceptor terminals possess the molecular machinery for chloride accumulation and for the generation of calcium-dependent chloride currents conducted through anoctamin 2 channels.
    Title: Targeted expression of anoctamin calcium-activated chloride channels in rod photoreceptor terminals of the rodent retina.
  3. the main functional features of ANO 1 and ANO 2 chloride channels in the nose and suggest their significance for nasal physiology.
    Title: Expression patterns of anoctamin 1 and anoctamin 2 chloride channels in the mammalian nose.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly calcium-gated chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables intracellularly calcium-gated chloride channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables phospholipid scramblase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chloride transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anoctamin 2; anoctamin-2
Names
anoctamin 2, calcium activated chloride channel
anoctamin-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431940.1 → NP_001418869.1  anoctamin 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    F1M3G8

  2. NM_001431941.1 → NP_001418870.1  anoctamin 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  3. NM_001431942.1 → NP_001418871.1  anoctamin 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    160200471..160541830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593038.3 → XP_017448527.2  anoctamin-2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JXB5
    Related
    ENSRNOP00000070208.2, ENSRNOT00000084240.3
    Conserved Domains (2) summary
    pfam04547
    Location:328 → 913
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:68 → 325
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  2. XM_063286858.1 → XP_063142928.1  anoctamin-2 isoform X1

    Related
    ENSRNOP00000030034.6, ENSRNOT00000032112.7

  3. XM_039108820.2 → XP_038964748.1  anoctamin-2 isoform X2

    Conserved Domains (2) summary
    pfam04547
    Location:190 → 775
    Anoctamin; Calcium-activated chloride channel
    pfam16178
    Location:19 → 187
    Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin

  4. XM_063286859.1 → XP_063142929.1  anoctamin-2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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