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Card11 caspase recruitment domain family, member 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100363332, updated on 2-Nov-2024

Summary

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Official Symbol
Card11provided by RGD
Official Full Name
caspase recruitment domain family, member 11provided by RGD
Primary source
RGD:2323211
See related
EnsemblRapid:ENSRNOG00000024277 AllianceGenome:RGD:2323211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable CARD domain binding activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of NF-kappaB transcription factor activity; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Predicted to be located in cytoplasm; immunological synapse; and membrane raft. Predicted to be part of CBM complex. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 141.6), Thymus (RPKM 53.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Card11 in Genome Data Viewer
Location:
12q11
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (18735088..18872045)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13621140..13758115)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (15700600..15844512)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095893 Neighboring gene uncharacterized LOC102547234 Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Congenital B cell lymphocytosis explained by novel germline CARD11 mutations. Snow AL, et al. J Exp Med, 2012 Nov 19. PMID 23129749, Free PMC Article
  2. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Lenz G, et al. Science, 2008 Mar 21. PMID 18323416
  3. The MAGUK family protein CARD11 is essential for lymphocyte activation. Hara H, et al. Immunity, 2003 Jun. PMID 12818158
  4. CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. Pomerantz JL, et al. EMBO J, 2002 Oct 1. PMID 12356734, Free PMC Article
  5. Characteristics of CARMA1-BCL10-MALT1-A20-NF-κB expression in T cell-acute lymphocytic leukemia. Ma Y, et al. Eur J Med Res, 2014 Nov 11. PMID 25384343, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CARD domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of T cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
involved_in TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymphocyte activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within thymic T cell selection ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CBM complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caspase recruitment domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419863.1 → NP_001406792.1  caspase recruitment domain-containing protein 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I5ZNJ6
    Related
    ENSRNOP00000079664.1, ENSRNOT00000092970.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    18735088..18872045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089959.2 → XP_038945887.1  caspase recruitment domain-containing protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNJ6, A0A8I6AA96
    Conserved Domains (4) summary
    COG1196
    Location:127 → 435
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:680 → 752
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd08808
    Location:22 → 107
    CARD_CARD11_CARMA1; Caspase activation and recruitment domain of CARD11-like proteins
    cl17036
    Location:777 → 839
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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