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Zfp965 zinc finger protein 965 [ Mus musculus (house mouse) ]

Gene ID: 100503949, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp965provided by MGI
Official Full Name
zinc finger protein 965provided by MGI
Primary source
MGI:MGI:3779822
See related
Ensembl:ENSMUSG00000078896 AllianceGenome:MGI:3779822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
668009; Gm8923
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZNF559-ZNF177 (ZNF559-ZNF177 readthrough). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 5.6), cerebellum adult (RPKM 4.6) and 25 other tissues See more
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Genomic context

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See Zfp965 in Genome Data Viewer
Location:
2 H4; 2 98.44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (175311818..175322346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (175470025..175480553)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:175197770-175198071 Neighboring gene zinc finger protein 968 Neighboring gene predicted gene, 57830 Neighboring gene predicted gene 4724 Neighboring gene STARR-positive B cell enhancer mm9_chr2:175295270-175295570 Neighboring gene predicted gene 11007 Neighboring gene STARR-positive B cell enhancer mm9_chr2:175702723-175703023 Neighboring gene zinc finger protein 969

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
KRAB box and zinc finger, C2H2 type domain containing protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242944.1 → NP_001229873.1  KRAB box and zinc finger, C2H2 type domain containing protein-like

    See identical proteins and their annotated locations for NP_001229873.1

    Status: VALIDATED

    Source sequence(s)
    CT010482
    Consensus CDS
    CCDS79872.1
    UniProtKB/TrEMBL
    A2BE20
    Related
    ENSMUSP00000104630.3, ENSMUST00000109002.9
    Conserved Domains (5) summary
    smart00349
    Location:23 → 64
    KRAB; krueppel associated box
    COG5048
    Location:43 → 302
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:180 → 200
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:23 → 62
    KRAB; KRAB box
    pfam13465
    Location:192 → 217
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    175311818..175322346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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