Iqschfp Iqcj and Schip1 fusion protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iqschfpprovided by MGI
Official Full Name: Iqcj and Schip1 fusion proteinprovided by MGI
Primary source: MGI:MGI:5439400
See related: Ensembl:ENSMUSG00000102422 AllianceGenome:MGI:5439400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Schip1; Gm21949; Iqcj-schip1; Schip-1-iqcj
Summary: This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (Iqcj) and schwannomin interacting protein 1 (Schip1) genes. This locus produces a transcript that is composed of in-frame exons from each individual gene. The resulting fusion protein is thought to be a component of the multimolecular complexes of axon initial segments and nodes of Ranvier, and it may play a role in calcium-mediated responses. [provided by RefSeq, Oct 2010]
Expression: Broad expression in cortex adult (RPKM 31.8), cerebellum adult (RPKM 30.6) and 16 other tissues See more
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Genomic context

Location:: 3 E1; 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (67799553..68533815)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (67892220..68626482)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D3Mit355 (e-PCR), detects polymorphism
- UniSTS:129796

36.MMHAP59FRD12.seq (e-PCR)
- UniSTS:124188

05.MMHAP62FRB8.seq (e-PCR)
- UniSTS:122825

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ankyrin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon ensheathment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon initial segment	IDA Inferred from Direct Assay more info	PubMed
located_in axon initial segment	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
NOT located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: IQCJ-SCHIP1 readthrough transcript protein

Names: IQ motif containing J-schwannomin interacting protein 1 fusion protein; IQ motif containing J-schwannomin interacting protein 1 readthrough

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.