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CBR3-AS1 CBR3 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 100506428, updated on 30-Oct-2023

Summary

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Official Symbol
CBR3-AS1provided by HGNC
Official Full Name
CBR3 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:43664
See related
Ensembl:ENSG00000236830 AllianceGenome:HGNC:43664
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PlncRNA1; PlncRNA-1
Expression
Ubiquitous expression in prostate (RPKM 4.6), salivary gland (RPKM 3.1) and 25 other tissues See more
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Genomic context

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Location:
21q22.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36131767..36156308, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34514794..34539161, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37504065..37528606, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18424 Neighboring gene CBR1 antisense RNA 1 Neighboring gene carbonyl reductase 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:37471927-37472788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:37477035-37477536 Neighboring gene uncharacterized LOC105369306 Neighboring gene MPRA-validated peak4410 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37485624-37486136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37506732-37507539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37507540-37508346 Neighboring gene MEMO1 pseudogene 1 Neighboring gene ribosomal protein S9 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37527648-37528315 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37528316-37528982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13281 Neighboring gene carbonyl reductase 3 Neighboring gene DOP1 leucine zipper like protein B Neighboring gene uncharacterized LOC124905016 Neighboring gene ribosomal protein L3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long Non-coding RNA CBR3 Antisense RNA 1 is Downregulated in Colorectal Cancer and Inhibits miR-29a-Mediated Cell Migration and Invasion. Yang M, et al. Mol Biotechnol, 2022 Jul. PMID 35107754
  2. Long Non-Coding RNAs Expression in Breast Cancer: CBR3-AS1 LncRNA as a Sensitive Biomarker. Torkashvand S, et al. Asian Pac J Cancer Prev, 2021 Sep 1. PMID 34582659, Free PMC Article
  3. LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway. Zhang M, et al. J Exp Clin Cancer Res, 2021 Jan 25. PMID 33494806, Free PMC Article
  4. High expression of Plnc RNA-1 promotes the progression of colorectal cancer. Song B, et al. J BUON, 2019 Jan-Feb. PMID 30941957
  5. Long non-coding RNA PlncRNA-1 promotes cell proliferation and hepatic metastasis in colorectal cancer. Jia GQ, et al. J Cell Biochem, 2018 Aug. PMID 29738066

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1.
    Title: LncRNA-CBR3-AS1 promotes and enhances the malignancy of ulcerative colitis via targeting miRNA-145-5p/FN1.
  2. LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway.
    Title: LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway.
  3. Long Non-coding RNA CBR3 Antisense RNA 1 is Downregulated in Colorectal Cancer and Inhibits miR-29a-Mediated Cell Migration and Invasion.
    Title: Long Non-coding RNA CBR3 Antisense RNA 1 is Downregulated in Colorectal Cancer and Inhibits miR-29a-Mediated Cell Migration and Invasion.
  4. Long Non-Coding RNAs Expression in Breast Cancer: CBR3-AS1 LncRNA as a Sensitive Biomarker.
    Title: Long Non-Coding RNAs Expression in Breast Cancer: CBR3-AS1 LncRNA as a Sensitive Biomarker.
  5. LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway.
    Title: LncRNA CBR3-AS1 regulates of breast cancer drug sensitivity as a competing endogenous RNA through the JNK1/MEK4-mediated MAPK signal pathway.
  6. LncRNA PlncRNA-1 accelerates the progression of prostate cancer by regulating PTEN/Akt axis.
    Title: LncRNA PlncRNA-1 accelerates the progression of prostate cancer by regulating PTEN/Akt axis.
  7. LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor beta1.
    Title: LncRNA PlncRNA-1 participates in rheumatoid arthritis by regulating transforming growth factor β1.
  8. Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of nonsmallcell lung cancer by sponging microRNA5093p and competitively upregulating HDAC9 expression.
    Title: Long noncoding RNA CBR3 antisense RNA 1 promotes the aggressive phenotypes of non‑small‑cell lung cancer by sponging microRNA‑509‑3p and competitively upregulating HDAC9 expression.
  9. Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis.
    Title: Hypomethylation of PlncRNA-1 promoter enhances bladder cancer progression through the miR-136-5p/Smad3 axis.
  10. patients with advanced stage retinoblastoma had higher levels of PlncRNA-1 expression than patients with early stage retinoblastoma. There was an inverse correlation between PlncRNA-1 expression and CBR3 expression in retinoblastoma tissues, and PlncRNA-1 negatively regulated mRNA and protein expressions of CBR3.
    Title: PlncRNA-1 is overexpressed in retinoblastoma and regulates retinoblastoma cell proliferation and motility through modulating CBR3.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • CBR3 antisense RNA 1 (non-protein coding)
  • prostate cancer-up-regulated long noncoding RNA 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_038892.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AL542398, AP000689, BI836686
    Related
    ENST00000413862.7

  2. NR_038893.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1.
    Source sequence(s)
    AP000689, BI836686
    Related
    ENST00000453159.6

  3. NR_038894.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 3' sequence, compared to variant 1.
    Source sequence(s)
    AP000689, BI836686
    Related
    ENST00000427491.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    36131767..36156308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    34514794..34539161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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