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TPBGL trophoblast glycoprotein like [ Homo sapiens (human) ]

Gene ID: 100507050, updated on 8-Mar-2024

Summary

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Official Symbol
TPBGLprovided by HGNC
Official Full Name
trophoblast glycoprotein likeprovided by HGNC
Primary source
HGNC:HGNC:44159
See related
Ensembl:ENSG00000261594 AllianceGenome:HGNC:44159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
mouse all
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Genomic context

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Location:
11q13.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75240774..75243704)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75170381..75173311)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74951819..74954749)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902717 Neighboring gene zinc finger DHHC-type containing 20 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74972903-74973402 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:74973761-74974692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74976727-74977228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74977229-74977728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74983603-74984104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74988922-74989422 Neighboring gene arrestin beta 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:74991005-74991880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75002568-75003068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75014529-75015343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75019873-75020374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75024683-75025599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75033894-75034520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75035773-75036398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75037071-75037602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75037603-75038135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5264 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75041995-75042528 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75042529-75043062 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75043063-75043596 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75044132-75044665 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75045734-75046268 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75046269-75046802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75051565-75052428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75052429-75053292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75057563-75058076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:75058077-75058590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5266 Neighboring gene microRNA 326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3763 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75062958-75063913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75092225-75092873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5267 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:75111125-75111988 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene ribosomal protein S3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
trophoblast glycoprotein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195528.2 → NP_001182457.1  trophoblast glycoprotein-like precursor

    See identical proteins and their annotated locations for NP_001182457.1

    Status: VALIDATED

    Source sequence(s)
    AP001972, BC007804, N54218
    Consensus CDS
    CCDS60895.1
    UniProtKB/Swiss-Prot
    P0DKB5
    Related
    ENSP00000474988.1, ENST00000562197.3
    Conserved Domains (3) summary
    sd00031
    Location:61 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:94 → 151
    LRR_8; Leucine rich repeat
    cl15307
    Location:234 → 267
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75240774..75243704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75170381..75173311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DKB5.1 GenPept UniProtKB/Swiss-Prot:P0DKB5

Gene LinkOut

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