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NPIPB9 nuclear pore complex interacting protein family member B9 [ Homo sapiens (human) ]

Gene ID: 100507607, updated on 17-Jun-2024

Summary

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Official Symbol
NPIPB9provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member B9provided by HGNC
Primary source
HGNC:HGNC:41987
See related
Ensembl:ENSG00000196993 AllianceGenome:HGNC:41987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 11.3), skin (RPKM 4.2) and 25 other tissues See more
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Genomic context

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See NPIPB9 in Genome Data Viewer
Location:
16p11.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28751787..28772864)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (29016081..29053452)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28763108..28784182)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit C Neighboring gene microRNA 6862-2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28742791-28743343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28751627-28752170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28752171-28752713 Neighboring gene uncharacterized LOC124903761 Neighboring gene pro-apoptotic WT1 regulator pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28770347-28770847 Neighboring gene phospholipase A2 group XK, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28791989-28792628 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
  2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member B9
Names
Nuclear pore complex-interacting protein family member B9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287250.3 → NP_001274179.1  nuclear pore complex-interacting protein family member B9

    See identical proteins and their annotated locations for NP_001274179.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC145285
    UniProtKB/Swiss-Prot
    F8VUA1, F8W1W9
    UniProtKB/TrEMBL
    B2RXF8
    Related
    ENSP00000350444.4, ENST00000357796.8
    Conserved Domains (3) summary
    TIGR02794
    Location:360 → 425
    tolA_full; TolA protein
    pfam06409
    Location:41 → 301
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. NR_176858.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC145285
    Related
    ENST00000550983.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    28751787..28772864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545693.4 → XP_011543995.1  nuclear pore complex-interacting protein family member B9 isoform X2

    UniProtKB/TrEMBL
    I3L0I5
    Conserved Domains (3) summary
    TIGR02794
    Location:389 → 454
    tolA_full; TolA protein
    pfam06409
    Location:70 → 330
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. XM_017022825.3 → XP_016878314.1  nuclear pore complex-interacting protein family member B9 isoform X4

    UniProtKB/TrEMBL
    I3L0I5

  3. XM_047433478.1 → XP_047289434.1  nuclear pore complex-interacting protein family member B9 isoform X6

    UniProtKB/TrEMBL
    A0A494C1T1

  4. XM_017022823.3 → XP_016878312.1  nuclear pore complex-interacting protein family member B9 isoform X3

    UniProtKB/TrEMBL
    I3L0I5

  5. XM_047433477.1 → XP_047289433.1  nuclear pore complex-interacting protein family member B9 isoform X5

    UniProtKB/TrEMBL
    I3L0I5

  6. XM_047433479.1 → XP_047289435.1  nuclear pore complex-interacting protein family member B9 isoform X8

    UniProtKB/TrEMBL
    A0A494C1T1

  7. XM_017022821.3 → XP_016878310.1  nuclear pore complex-interacting protein family member B9 isoform X1

    UniProtKB/TrEMBL
    I3L0I5

  8. XM_017022827.3 → XP_016878316.1  nuclear pore complex-interacting protein family member B9 isoform X7

  9. XM_047433481.1 → XP_047289437.1  nuclear pore complex-interacting protein family member B9 isoform X10

  10. XM_047433480.1 → XP_047289436.1  nuclear pore complex-interacting protein family member B9 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    29016081..29053452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379339.1 → XP_054235314.1  nuclear pore complex-interacting protein family member B9 isoform X11

    UniProtKB/TrEMBL
    B2RXF8

  2. XM_054379342.1 → XP_054235317.1  nuclear pore complex-interacting protein family member B9 isoform X12

    UniProtKB/TrEMBL
    B2RXF8

  3. XM_054379338.1 → XP_054235313.1  nuclear pore complex-interacting protein family member B9 isoform X11

    UniProtKB/TrEMBL
    B2RXF8

  4. XM_054379344.1 → XP_054235319.1  nuclear pore complex-interacting protein family member B9 isoform X13

    UniProtKB/TrEMBL
    I3L0I5

  5. XM_054379337.1 → XP_054235312.1  nuclear pore complex-interacting protein family member B9 isoform X11

    UniProtKB/TrEMBL
    B2RXF8

  6. XM_054379340.1 → XP_054235315.1  nuclear pore complex-interacting protein family member B9 isoform X4

    UniProtKB/TrEMBL
    I3L0I5

  7. XM_054379345.1 → XP_054235320.1  nuclear pore complex-interacting protein family member B9 isoform X6

    UniProtKB/TrEMBL
    O75199

  8. XM_054379341.1 → XP_054235316.1  nuclear pore complex-interacting protein family member B9 isoform X4

    UniProtKB/TrEMBL
    I3L0I5

  9. XM_054379343.1 → XP_054235318.1  nuclear pore complex-interacting protein family member B9 isoform X5

    UniProtKB/TrEMBL
    I3L0I5

  10. XM_054379346.1 → XP_054235321.1  nuclear pore complex-interacting protein family member B9 isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001287251.3: Suppressed sequence

    Description
    NM_001287251.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F8W1W9.2 GenPept UniProtKB/Swiss-Prot:F8W1W9

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