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SMIM35 small integral membrane protein 35 [ Homo sapiens (human) ]

Gene ID: 100526771, updated on 2-Nov-2024

Summary

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Official Symbol
SMIM35provided by HGNC
Official Full Name
small integral membrane protein 35provided by HGNC
Primary source
HGNC:HGNC:44179
See related
Ensembl:ENSG00000255274 AllianceGenome:HGNC:44179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMPRSS4-AS1
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See SMIM35 in Genome Data Viewer
Location:
11q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118003634..118086963, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118020013..118104849, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (117874349..117957678, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117778029-117778529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117784655-117785647 Neighboring gene transmembrane serine protease 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:117802800-117803339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117803340-117803878 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19102 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:117843533-117843947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5580 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117869597-117870098 Neighboring gene interleukin 10 receptor subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117881450-117881950 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117935307-117935808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:117947648-117948243 Neighboring gene RNA, 7SL, cytoplasmic 828, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13014 Neighboring gene uncharacterized LOC105369517 Neighboring gene transmembrane serine protease 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_19222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118000597-118001098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118001099-118001598 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:118014519-118015718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5583 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3943 Neighboring gene sodium voltage-gated channel beta subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small integral membrane protein 35
Names
TMPRSS4 antisense RNA 1 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354434.2 → NP_001341363.1  small integral membrane protein 35 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB231756, AB231757, AP000665, AP002962

  2. NM_001394164.1 → NP_001381093.1  small integral membrane protein 35 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP000665, AP002962

  3. NM_001394165.1 → NP_001381094.1  small integral membrane protein 35 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP000665, AP002962
    Consensus CDS
    CCDS91602.1
    UniProtKB/Swiss-Prot
    A0A1B0GVV1
    Related
    ENSP00000509259.1, ENST00000689828.1

  4. NM_001394166.1 → NP_001381095.1  small integral membrane protein 35 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP000665, AP002962

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    118003634..118086963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448283.2 → XP_024304051.1  small integral membrane protein 35 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    118020013..118104849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367368.1 → XP_054223343.1  small integral membrane protein 35 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1B0GVV1.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GVV1

Gene LinkOut

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