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HSPE1-MOB4 HSPE1-MOB4 readthrough [ Homo sapiens (human) ]

Gene ID: 100529241, updated on 8-Mar-2024

Summary

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Official Symbol
HSPE1-MOB4provided by HGNC
Official Full Name
HSPE1-MOB4 readthroughprovided by HGNC
Primary source
HGNC:HGNC:49184
See related
Ensembl:ENSG00000270757 AllianceGenome:HGNC:49184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPE1-PHOCN
Summary
This locus represents naturally occurring read-through transcription between the neighboring HSPE1 (heat shock 10kDa protein 1 (chaperonin 10)) and MOB4 (MOB family member 4, phocein) genes on chromosome 2. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in adrenal (RPKM 42.3), kidney (RPKM 19.1) and 24 other tissues See more
Orthologs
all
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Genomic context

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See HSPE1-MOB4 in Genome Data Viewer
Location:
2q33.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (197500379..197553699)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197983980..198037300)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198365103..198418423)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907951 Neighboring gene coenzyme Q10B Neighboring gene small nucleolar RNA, H/ACA box 105B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16939 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12214 Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12215 Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene MOB family member 4, phocein Neighboring gene uncharacterized LOC124907952 Neighboring gene RNY5 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:198447337-198447852 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198451577-198452275 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:198452276-198452973 Neighboring gene raftlin family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16940 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198484019-198484523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:198484980-198485480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198532470-198533059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:198533060-198533648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16943 Neighboring gene methionyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  2. Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission. St-Denis N, et al. Mol Cell Proteomics, 2015 Apr. PMID 25659891, Free PMC Article
  3. EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. Pan Z, et al. Mol Cancer, 2022 Jan 14. PMID 35031058, Free PMC Article
  4. A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection. Yeung ATY, et al. mBio, 2019 Oct 8. PMID 31594818, Free PMC Article
  5. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. Yuan J, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36244648, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough HSPE1-MOB4

Included genes: HSPE1, MOB4

Homology

General protein information

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Preferred Names
HSPE1-MOB4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001202485.2 → NP_001189414.1  HSPE1-MOB4 protein

    See identical proteins and their annotated locations for NP_001189414.1

    Status: REVIEWED

    Source sequence(s)
    AC020550
    UniProtKB/TrEMBL
    S4R3N1
    Related
    ENSP00000474534.1, ENST00000604458.1
    Conserved Domains (2) summary
    cd00320
    Location:8 → 57
    cpn10; Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It ...
    pfam03637
    Location:89 → 243
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    197500379..197553699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    197983980..198037300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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