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COMMD3-BMI1 COMMD3-BMI1 readthrough [ Homo sapiens (human) ]

Gene ID: 100532731, updated on 10-Oct-2023

Summary

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Official Symbol
COMMD3-BMI1provided by HGNC
Official Full Name
COMMD3-BMI1 readthroughprovided by HGNC
Primary source
HGNC:HGNC:48326
See related
Ensembl:ENSG00000269897 AllianceGenome:HGNC:48326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMI1; PCGF4; RNF51
Summary
This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in testis (RPKM 24.5), endometrium (RPKM 22.5) and 25 other tissues See more
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Genomic context

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Location:
10p12.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (22316388..22331484)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (22335422..22350518)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (22605317..22620413)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376447 Neighboring gene uncharacterized LOC100130992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22542487-22543183 Neighboring gene ribosomal protein L31 pseudogene 45 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22568695-22569196 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22569197-22569696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2205 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2207 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2208 Neighboring gene COMM domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:22629212-22629998 Neighboring gene BMI1 proto-oncogene, polycomb ring finger Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22634454-22635270 Neighboring gene sperm associated antigen 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3131 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22697232-22697772 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:22697773-22698311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2210 Neighboring gene uncharacterized LOC105376449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22726272-22726772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:22726773-22727273 Neighboring gene long intergenic non-protein coding RNA 3027

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. Prakash T, et al. PLoS One, 2010 Oct 12. PMID 20967262, Free PMC Article
  2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Oliviero G, et al. Sci Rep, 2015 Dec 21. PMID 26687479, Free PMC Article
  3. Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy. Ohnstad AE, et al. EMBO J, 2020 Dec 15. PMID 33226137, Free PMC Article
  4. A High-Density Map for Navigating the Human Polycomb Complexome. Hauri S, et al. Cell Rep, 2016 Oct 4. PMID 27705803
  5. HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation. Yuan J, et al. Cell Mol Gastroenterol Hepatol, 2023. PMID 36244648, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434I153

General protein information

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Preferred Names
COMMD3-BMI1 read-through protein
Names
Polycomb complex protein BMI-1
Polycomb group RING finger protein 4
RING finger protein 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204062.2 → NP_001190991.1  COMMD3-BMI1 read-through protein

    Status: VALIDATED

    Source sequence(s)
    AK313235, AL158211
    UniProtKB/TrEMBL
    R4GMX3
    Related
    ENSP00000473391.1, ENST00000602390.5
    Conserved Domains (3) summary
    pfam00097
    Location:161 → 199
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam07258
    Location:20 → 125
    HCaRG; HCaRG protein
    pfam16207
    Location:291 → 369
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    22316388..22331484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    22335422..22350518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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