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LOC100533493 protein kinase C II [ Aplysia californica (California sea hare) ]

Gene ID: 100533493, updated on 14-Dec-2023

Summary

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Gene symbol
LOC100533493
Gene description
protein kinase C II
See related
EnsemblRapid:LOC100533493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Aplysia californica
Lineage
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea; Aplysiidae; Aplysia
Also known as
PRKC; PRKC2
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Genomic context

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See LOC100533493 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
102 current AplCal3.0 (GCF_000002075.1) Unplaced Scaffold NW_004797396.1 (711490..742946, complement)

NW_004797396.1Genomic Context describing neighboring genes Neighboring gene 3-oxo-5-alpha-steroid 4-dehydrogenase 1 Neighboring gene uncharacterized LOC118477528 Neighboring gene iron-sulfur cluster assembly 2 homolog, mitochondrial Neighboring gene protein FAM177A1 Neighboring gene nephrocystin-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004797396 Unplaced Scaffold Reference AplCal3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Autophosphorylation of the C2 domain inhibits translocation of the novel protein kinase C (nPKC) Apl II. Farah CA, et al. J Neurochem, 2012 Nov. PMID 22913526
  2. The C2 domain of the Ca(2+)-independent protein kinase C Apl II inhibits phorbol ester binding to the C1 domain in a phosphatidic acid-sensitive manner. Pepio AM, et al. Biochemistry, 1998 Feb 3. PMID 9477951
  3. Rictor regulates phosphorylation of the novel protein kinase C Apl II in Aplysia sensory neurons. Labban M, et al. J Neurochem, 2012 Sep. PMID 22774769
  4. Protein kinase C acts as a molecular detector of firing patterns to mediate sensory gating in Aplysia. Wan Q, et al. Nat Neurosci, 2012 Jul 8. PMID 22772333, Free PMC Article
  5. The role of C2 domains in Ca2+-activated and Ca2+-independent protein kinase Cs in aplysia. Pepio AM, et al. J Biol Chem, 1998 Jul 24. PMID 9668085

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An important regulatory role is discovered for Aplysia PKC N-terminal C2 domain phosphorylation, demonstrating the critical regulation of PKC translocation.
    Title: Autophosphorylation of the C2 domain inhibits translocation of the novel protein kinase C (nPKC) Apl II.
  2. Rictor is implicated in phosphorylation of a novel protein kinase C (PKC) during synaptic plasticity, suggesting an additional role for Rictor in regulating localization of PKCs.
    Title: Rictor regulates phosphorylation of the novel protein kinase C Apl II in Aplysia sensory neurons.
  3. Protein kinase C acts as a molecular detector of firing patterns to mediate sensory gating in Aplysia.
    Title: Protein kinase C acts as a molecular detector of firing patterns to mediate sensory gating in Aplysia.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calcium-independent protein kinase C
Names
APL II
NP_001191401.1
XP_035825100.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204472.1 → NP_001191401.1  calcium-independent protein kinase C

    See identical proteins and their annotated locations for NP_001191401.1

    Status: PROVISIONAL

    Source sequence(s)
    M94884
    UniProtKB/Swiss-Prot
    Q16975
    Related
    NP_001191401.1, NM_001204472.1
    Conserved Domains (4) summary
    cd04014
    Location:8 → 140
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    smart00220
    Location:403 → 663
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05591
    Location:407 → 728
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    pfam00130
    Location:248 → 298
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Aplysia californica Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference AplCal3.0 Primary Assembly

Genomic

  1. NW_004797396.1 Reference AplCal3.0 Primary Assembly

    Range
    711490..742946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_035969207.1 → XP_035825100.1  calcium-independent protein kinase C isoform X1

    Related
    XP_035825100.1, XM_035969207.1
    Conserved Domains (4) summary
    cd04014
    Location:8 → 140
    C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
    cd05591
    Location:381 → 702
    STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
    cd20835
    Location:171 → 230
    C1_nPKC_epsilon-like_rpt1; first protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
    cd20838
    Location:246 → 300
    C1_nPKC_epsilon-like_rpt2; second protein kinase C conserved region 1 (C1 domain) found in novel protein kinase C (nPKC) epsilon, eta, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16975.1 GenPept UniProtKB/Swiss-Prot:Q16975

Gene LinkOut

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Molecular Biology Databases