U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TJP1 tight junction protein 1 [ Sus scrofa (pig) ]

Gene ID: 100736682, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
TJP1provided by VGNC
Official Full Name
tight junction protein 1provided by VGNC
Primary source
VGNC:VGNC:94005
See related
Ensembl:ENSSSCG00000004854
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
zo1
Expression
Ubiquitous expression in lung (RPKM 38.0), ovary (RPKM 22.8) and 8 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TJP1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
31
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (144930387..145195857, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (161175436..161284250, complement)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102162639 Neighboring gene uncharacterized LOC106509044 Neighboring gene SEH1 like nucleoporin Neighboring gene ferritin light chain pseudogene Neighboring gene threonyl-tRNA synthetase 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tight junction protein ZO-1
Names
zonula occludens 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    144930387..145195857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021098856.1 → XP_020954515.1  tight junction protein ZO-1 isoform X7

    UniProtKB/TrEMBL
    A0A4X1UB44
    Conserved Domains (8) summary
    smart00218
    Location:1646 → 1752
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610 → 674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708 → 887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276 → 356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115 → 200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518 → 594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl26464
    Location:1108 → 1504
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:953 → 1208
    dnaA; chromosomal replication initiation protein; Provisional

  2. XM_021098848.1 → XP_020954507.1  tight junction protein ZO-1 isoform X6

    UniProtKB/TrEMBL
    A0A4X1UB44
    Conserved Domains (8) summary
    cd12026
    Location:610 → 674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708 → 887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276 → 356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115 → 200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518 → 594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1649 → 1738
    ZU5; ZU5 domain
    cl26464
    Location:1108 → 1504
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:953 → 1208
    dnaA; chromosomal replication initiation protein; Provisional

  3. XM_021098843.1 → XP_020954502.1  tight junction protein ZO-1 isoform X4

    UniProtKB/TrEMBL
    A0A4X1UB44
    Conserved Domains (8) summary
    cd12026
    Location:610 → 674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708 → 887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276 → 356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115 → 200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518 → 594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1649 → 1748
    ZU5; ZU5 domain
    cl26464
    Location:1108 → 1504
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:953 → 1208
    dnaA; chromosomal replication initiation protein; Provisional

  4. XM_021098836.1 → XP_020954495.1  tight junction protein ZO-1 isoform X3

    UniProtKB/TrEMBL
    A0A8D0VFE9
    Conserved Domains (7) summary
    smart00218
    Location:1726 → 1832
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:610 → 674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708 → 887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276 → 356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115 → 200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518 → 594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl26464
    Location:1025 → 1584
    Atrophin-1; Atrophin-1 family

  5. XM_021098833.1 → XP_020954492.1  tight junction protein ZO-1 isoform X2

    UniProtKB/TrEMBL
    A0A8D0VFE9
    Conserved Domains (7) summary
    cd12026
    Location:610 → 674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708 → 887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276 → 356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115 → 200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518 → 594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1729 → 1818
    ZU5; ZU5 domain
    cl26464
    Location:1025 → 1584
    Atrophin-1; Atrophin-1 family

  6. XM_021098827.1 → XP_020954486.1  tight junction protein ZO-1 isoform X1

    UniProtKB/TrEMBL
    A0A287BF71, A0A8D0VFE9
    Related
    ENSSSCP00000054972.2, ENSSSCT00000051548.3
    Conserved Domains (7) summary
    cd12026
    Location:610 → 674
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:708 → 887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:276 → 356
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:115 → 200
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:518 → 594
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1729 → 1828
    ZU5; ZU5 domain
    cl26464
    Location:1025 → 1584
    Atrophin-1; Atrophin-1 family

  7. XM_021098845.1 → XP_020954504.1  tight junction protein ZO-1 isoform X5

    UniProtKB/TrEMBL
    A0A4X1U620
    Conserved Domains (7) summary
    cd12026
    Location:517 → 581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615 → 794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183 → 263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425 → 501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1636 → 1735
    ZU5; ZU5 domain
    cl26464
    Location:932 → 1491
    Atrophin-1; Atrophin-1 family

  8. XM_021098886.1 → XP_020954545.1  tight junction protein ZO-1 isoform X13

    UniProtKB/TrEMBL
    A0A8D0KB29
    Conserved Domains (8) summary
    cd12026
    Location:517 → 581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615 → 794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183 → 263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425 → 501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1556 → 1645
    ZU5; ZU5 domain
    cl26464
    Location:1015 → 1411
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:860 → 1115
    dnaA; chromosomal replication initiation protein; Provisional

  9. XM_021098878.1 → XP_020954537.1  tight junction protein ZO-1 isoform X11

    UniProtKB/TrEMBL
    A0A287AHM9, A0A8D0PHL5
    Related
    ENSSSCP00000043392.3, ENSSSCT00000057241.3
    Conserved Domains (8) summary
    cd12026
    Location:517 → 581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615 → 794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183 → 263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425 → 501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1556 → 1655
    ZU5; ZU5 domain
    cl26464
    Location:1015 → 1411
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:860 → 1115
    dnaA; chromosomal replication initiation protein; Provisional

  10. XM_021098866.1 → XP_020954525.1  tight junction protein ZO-1 isoform X9

    UniProtKB/TrEMBL
    A0A8D1D5K1
    Related
    ENSSSCP00000005227.4, ENSSSCT00000005359.4
    Conserved Domains (7) summary
    cd12026
    Location:517 → 581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615 → 794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183 → 263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425 → 501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1636 → 1725
    ZU5; ZU5 domain
    cl26464
    Location:932 → 1491
    Atrophin-1; Atrophin-1 family

  11. XM_021098891.1 → XP_020954550.1  tight junction protein ZO-1 isoform X14

    UniProtKB/TrEMBL
    A0A8D0KB29
    Conserved Domains (8) summary
    smart00218
    Location:1553 → 1659
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:517 → 581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615 → 794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183 → 263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425 → 501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl26464
    Location:1015 → 1411
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:860 → 1115
    dnaA; chromosomal replication initiation protein; Provisional

  12. XM_003480423.4 → XP_003480471.3  tight junction protein ZO-1 isoform X10

    UniProtKB/TrEMBL
    A0A286ZRD4, A0A8D1D5K1
    Related
    ENSSSCP00000034183.3, ENSSSCT00000063278.3
    Conserved Domains (7) summary
    smart00218
    Location:1633 → 1739
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:517 → 581
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:615 → 794
    GuKc; Guanylate kinase homologues
    smart00228
    Location:183 → 263
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:425 → 501
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl26464
    Location:932 → 1491
    Atrophin-1; Atrophin-1 family

  13. XM_021098860.1 → XP_020954519.1  tight junction protein ZO-1 isoform X8

    UniProtKB/TrEMBL
    A0A8D0KCJ1
    Conserved Domains (7) summary
    cd12026
    Location:505 → 569
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:603 → 782
    GuKc; Guanylate kinase homologues
    smart00228
    Location:171 → 251
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:10 → 95
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:413 → 489
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1624 → 1723
    ZU5; ZU5 domain
    cl26464
    Location:920 → 1479
    Atrophin-1; Atrophin-1 family

  14. XM_021098896.1 → XP_020954555.1  tight junction protein ZO-1 isoform X15

    UniProtKB/TrEMBL
    A0A8D0KB29
    Conserved Domains (8) summary
    smart00218
    Location:1541 → 1647
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd12026
    Location:505 → 569
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:603 → 782
    GuKc; Guanylate kinase homologues
    smart00228
    Location:171 → 251
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:10 → 95
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:413 → 489
    PDZ; PDZ domain (Also known as DHR or GLGF)
    cl26464
    Location:1003 → 1399
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:848 → 1103
    dnaA; chromosomal replication initiation protein; Provisional

  15. XM_021098883.1 → XP_020954542.1  tight junction protein ZO-1 isoform X12

    UniProtKB/TrEMBL
    A0A4X1UBD2, A0A8D0K829
    Related
    ENSSSCP00000019275.3, ENSSSCT00000024292.4
    Conserved Domains (8) summary
    cd12026
    Location:505 → 569
    SH3_ZO-1; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 1
    smart00072
    Location:603 → 782
    GuKc; Guanylate kinase homologues
    smart00228
    Location:171 → 251
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:10 → 95
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00595
    Location:413 → 489
    PDZ; PDZ domain (Also known as DHR or GLGF)
    pfam00791
    Location:1544 → 1643
    ZU5; ZU5 domain
    cl26464
    Location:1003 → 1399
    Atrophin-1; Atrophin-1 family
    cl28271
    Location:848 → 1103
    dnaA; chromosomal replication initiation protein; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.