Alyreffm11 Aly/REF export factor family member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Alyreffm11provided by MGI
Official Full Name: Aly/REF export factor family member 11provided by MGI
Primary source: MGI:MGI:5434648
See related: Ensembl:ENSMUSG00000091779 AllianceGenome:MGI:5434648
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm21293
Summary: Predicted to enable C5-methylcytidine-containing RNA reader activity and mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of catalytic step 2 spliceosome; exon-exon junction complex; and transcription export complex. Predicted to be active in nucleus. Predicted to colocalize with chromosome, telomeric region. Orthologous to human ALYREF (Aly/REF export factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 10 D1; 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (103978848..103981288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (104142987..104145427)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C5-methylcytidine-containing RNA reader activity	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of exon-exon junction complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA and export factor-binding protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270898.1 → NP_001257827.1 RNA and export factor-binding protein 2-like

See identical proteins and their annotated locations for NP_001257827.1

Status: VALIDATED

Source sequence(s)

AC192091

UniProtKB/TrEMBL

M0QWB2, M0QWR4

Related

ENSMUSP00000137742.2, ENSMUST00000181634.8

Conserved Domains (3) summary

COG0724
Location:79 → 186

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12680
Location:86 → 160

RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins

pfam07078
Location:6 → 59

FYTT; Forty-two-three protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

103978848..103981288

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313753.1 → XP_017169242.1 RNA and export factor-binding protein 2-like isoform X1

UniProtKB/TrEMBL

M0QWB2, M0QWR4

Conserved Domains (3) summary

cd12680
Location:86 → 160

RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins

TIGR01648
Location:26 → 179

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

pfam13865
Location:169 → 230

FoP_duplication; C-terminal duplication domain of Friend of PRMT1
XM_030244792.1 → XP_030100652.1 RNA and export factor-binding protein 2-like isoform X2

UniProtKB/TrEMBL

M0QWB2, M0QWR4

Conserved Domains (3) summary

cd12680
Location:86 → 160

RRM_THOC4; RNA recognition motif in THO complex subunit 4 (THOC4) and similar proteins

TIGR01648
Location:26 → 179

hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

pfam13865
Location:169 → 229

FoP_duplication; C-terminal duplication domain of Friend of PRMT1