Kbtbd7 kelch repeat and BTB domain containing 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kbtbd7provided by RGD
Official Full Name: kelch repeat and BTB domain containing 7provided by RGD
Primary source: RGD:6501695
See related: EnsemblRapid:ENSRNOG00000064764 AllianceGenome:RGD:6501695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of Rac protein signal transduction. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KBTBD7 (kelch repeat and BTB domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 15q12

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (61215957..61220536)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (54806878..54811457)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (61692041..61696506)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kelch repeat and BTB domain-containing protein 7

Names: kelch repeat and BTB (POZ) domain containing 7; kelch repeat and BTB domain-containing protein 7-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302944.1 → NP_001289873.1 kelch repeat and BTB domain-containing protein 7

See identical proteins and their annotated locations for NP_001289873.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I6AT07, A6HTZ2

Related

ENSRNOP00000097623.1, ENSRNOT00000106634.2

Conserved Domains (5) summary

smart00875
Location:173 → 274

BACK; BTB And C-terminal Kelch

PHA03098
Location:55 → 554

PHA03098; kelch-like protein; Provisional

sd00038
Location:394 → 431

Kelch; KELCH repeat [structural motif]

pfam00651
Location:53 → 164

BTB; BTB/POZ domain

pfam01344
Location:435 → 481

Kelch_1; Kelch motif