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Chadl chondroadherin-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 100910434, updated on 10-Oct-2024

Summary

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Symbol
Chadlprovided by RGD
Full Name
chondroadherin-likeprovided by RGD
Primary source
RGD:6504353
See related
EnsemblRapid:ENSRNOG00000024631 AllianceGenome:RGD:6504353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable collagen binding activity and collagen fibril binding activity. Predicted to be involved in negative regulation of chondrocyte differentiation and negative regulation of collagen fibril organization. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 14.6), Lung (RPKM 13.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Chadl in Genome Data Viewer
Location:
7q34
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (115085447..115097565, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (113205323..113218678, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122915847..122929127, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene E1A binding protein p300 Neighboring gene ribosomal protein L35A like 1 Neighboring gene L3MBTL histone methyl-lysine binding protein 2 Neighboring gene uncharacterized LOC120093698 Neighboring gene RAN GTPase activating protein 1 Neighboring gene zinc finger CCCH-type containing 7B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. Tillgren V, et al. J Biol Chem, 2015 Jan 9. PMID 25451920, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables collagen fibril binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chondroadherin-like; chondroadherin-like protein
Names
chondroadherin-like protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432133.1 → NP_001419062.1  chondroadherin-like precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    F1LVK3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    115085447..115097565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264686.1 → XP_063120756.1  chondroadherin-like protein isoform X2

    Related
    ENSRNOP00000102525.1, ENSRNOT00000125706.1

  2. XM_063264685.1 → XP_063120755.1  chondroadherin-like protein isoform X1

  3. XM_063264684.1 → XP_063120754.1  chondroadherin-like protein isoform X1

    UniProtKB/TrEMBL
    F1LVK3

  4. XM_008765809.4 → XP_008764031.1  chondroadherin-like protein isoform X1

    See identical proteins and their annotated locations for XP_008764031.1

    UniProtKB/TrEMBL
    A6HT11, F1LVK3
    Related
    ENSRNOP00000000205.6, ENSRNOT00000000205.8
    Conserved Domains (6) summary
    smart00013
    Location:27 → 59
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:663 → 711
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:381 → 617
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:656 → 667
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:58 → 81
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:437 → 497
    LRR_8; Leucine rich repeat
Nucleotide Protein Strain
Heading Accession and Version

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