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Derl2 derlin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100910823, updated on 2-Nov-2024

Summary

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Official Symbol
Derl2provided by RGD
Official Full Name
derlin 2provided by RGD
Primary source
RGD:6496100
See related
EnsemblRapid:ENSRNOG00000055466 AllianceGenome:RGD:6496100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signal recognition particle binding activity. Predicted to be involved in several processes, including ERAD pathway; endoplasmic reticulum unfolded protein response; and negative regulation of retrograde protein transport, ER to cytosol. Predicted to act upstream of or within retrograde protein transport, ER to cytosol and suckling behavior. Predicted to be located in early endosome; endoplasmic reticulum membrane; and late endosome. Orthologous to human DERL2 (derlin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 241.4), Kidney (RPKM 95.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Derl2 in Genome Data Viewer
Location:
10q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (56226340..56238038, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55727764..55739442, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57641682..57653554, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene complement C1q binding protein Neighboring gene DEAH-box helicase 33 Neighboring gene MIS12 kinetochore complex component Neighboring gene chromobox protein homolog 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of F-LANa, upregulated in human liver cancer. Ying H, et al. Biochem Biophys Res Commun, 2001 Aug 17. PMID 11500051
  2. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Dougan SK, et al. Mol Cell Biol, 2011 Mar. PMID 21220515, Free PMC Article
  3. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. Oda Y, et al. J Cell Biol, 2006 Jan 30. PMID 16449189, Free PMC Article
  4. A membrane protein required for dislocation of misfolded proteins from the ER. Lilley BN, et al. Nature, 2004 Jun 24. PMID 15215855
  5. Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP. Kadowaki H, et al. Cell Rep, 2015 Nov 3. PMID 26565908

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables signal recognition particle binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within suckling behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
derlin-2
Names
Der1-like domain family, member 2
derlin-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399430.1 → NP_001386359.1  derlin-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HGB7
    Related
    ENSRNOP00000090568.2, ENSRNOT00000096118.2
    Conserved Domains (1) summary
    pfam04511
    Location:13 → 203
    DER1; Der1-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    56226340..56238038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087317.2 → XP_038943245.1  derlin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AMH0, A0A8I6GIB4, A6HGB5
    Related
    ENSRNOP00000095156.1, ENSRNOT00000096117.2
    Conserved Domains (1) summary
    pfam04511
    Location:13 → 202
    DER1; Der1-like family

  2. XM_063268246.1 → XP_063124316.1  derlin-2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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