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Mtfr2 mitochondrial fission regulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100911069, updated on 2-Nov-2024

Summary

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Official Symbol
Mtfr2provided by RGD
Official Full Name
mitochondrial fission regulator 2provided by RGD
Primary source
RGD:6494892
See related
EnsemblRapid:ENSRNOG00000078862 AllianceGenome:RGD:6494892
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dufd1
Summary
Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be located in mitochondrion. Orthologous to human MTFR2 (mitochondrial fission regulator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 104.1), Spleen (RPKM 38.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtfr2 in Genome Data Viewer
Location:
1p12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16942814..16958218)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (15123232..15138632)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15834779..15850424)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene BCL2-associated transcription factor 1 Neighboring gene phosphodiesterase 7B Neighboring gene uncharacterized LOC134484964 Neighboring gene uncharacterized LOC134484963

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The nuclear genes Mtfr1 and Dufd1 regulate mitochondrial dynamic and cellular respiration. Monticone M, et al. J Cell Physiol, 2010 Nov. PMID 20568109
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
  
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial fission regulator 2
Names
DUF729 domain containing 1
protein FAM54A-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290110.1 → NP_001277039.1  mitochondrial fission regulator 2

    See identical proteins and their annotated locations for NP_001277039.1

    Status: PROVISIONAL

    Source sequence(s)
    BC159435
    UniProtKB/Swiss-Prot
    B0K035
    Related
    ENSRNOP00000072258.1, ENSRNOT00000079069.3
    Conserved Domains (1) summary
    pfam05308
    Location:40 → 307
    Mito_fiss_reg; Mitochondrial fission regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    16942814..16958218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284133.1 → XP_063140203.1  mitochondrial fission regulator 2 isoform X1

  2. XM_039103500.2 → XP_038959428.1  mitochondrial fission regulator 2 isoform X1

    Conserved Domains (1) summary
    pfam05308
    Location:1 → 129
    Mito_fiss_reg; Mitochondrial fission regulator
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B0K035.1 GenPept UniProtKB/Swiss-Prot:B0K035

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials