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POTEB POTE ankyrin domain family member B [ Homo sapiens (human) ]

Gene ID: 100996331, updated on 3-Apr-2024

Summary

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Official Symbol
POTEBprovided by HGNC
Official Full Name
POTE ankyrin domain family member Bprovided by HGNC
Primary source
HGNC:HGNC:33734
See related
Ensembl:ENSG00000233917 MIM:608912; AllianceGenome:HGNC:33734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A26B1; POTE15; POTEB2; CT104.5; POTE-15
Expression
Restricted expression toward testis (RPKM 5.8) See more
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Genomic context

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Location:
15q11.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (21846329..21877735, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (22051853..22083259, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379207 Neighboring gene microRNA 3118-4 Neighboring gene RNA, U6 small nuclear 631, pseudogene Neighboring gene vomeronasal 1 receptor 62 pseudogene Neighboring gene vomeronasal 1 receptor 63 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Personalized copy number and segmental duplication maps using next-generation sequencing. Alkan C, et al. Nat Genet, 2009 Oct. PMID 19718026, Free PMC Article
  2. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. Bera TK, et al. Gene, 2004 Aug 4. PMID 15276201
  3. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Bera TK, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12475935, Free PMC Article
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171
  5. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identifies POTEB as being one of 30 genes with the most variable copy numbers in three human genomes.
    Title: Personalized copy number and segmental duplication maps using next-generation sequencing.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119373

General protein information

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Preferred Names
POTE ankyrin domain family member B
Names
ANKRD26-like family B, member 1
POTE ankyrin domain family member B2
cancer/testis antigen family 104, member 5
prostate, ovary, testis-expressed protein on chromosome 15
protein expressed in prostate, ovary, testis, and placenta 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277304.2 → NP_001264233.1  POTE ankyrin domain family member B

    See identical proteins and their annotated locations for NP_001264233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the supported protein.
    Source sequence(s)
    AC183089
    Consensus CDS
    CCDS59250.1
    UniProtKB/Swiss-Prot
    A0A0A6YYL3, H3BUK9, Q495V7
    Related
    ENSP00000457689.2, ENST00000439682.2
    Conserved Domains (4) summary
    cd00204
    Location:130 → 255
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:201 → 232
    ANK; ANK repeat [structural motif]
    pfam14915
    Location:489 → 542
    CCDC144C; CCDC144C protein coiled-coil region
    cl25732
    Location:412 → 542
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_102391.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC183089
    Related
    ENST00000435397.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    21846329..21877735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021858.2 → XP_016877347.1  POTE ankyrin domain family member B isoform X3

    UniProtKB/TrEMBL
    A0A0G2JQ08

  2. XM_047432072.1 → XP_047288028.1  POTE ankyrin domain family member B isoform X1

  3. XM_011543794.3 → XP_011542096.1  POTE ankyrin domain family member B isoform X2

    See identical proteins and their annotated locations for XP_011542096.1

    UniProtKB/TrEMBL
    A0A0G2JQ08
    Conserved Domains (4) summary
    cd00204
    Location:130 → 255
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:140 → 232
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:106 → 156
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:201 → 232
    ANK; ANK repeat [structural motif]

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    3023460..3054807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0A6YYL3.1 GenPept UniProtKB/Swiss-Prot:A0A0A6YYL3

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