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NPY4R2 neuropeptide Y receptor Y4-2 [ Homo sapiens (human) ]

Gene ID: 100996758, updated on 3-Apr-2024

Summary

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Official Symbol
NPY4R2provided by HGNC
Official Full Name
neuropeptide Y receptor Y4-2provided by HGNC
Primary source
HGNC:HGNC:52383
See related
Ensembl:ENSG00000264717 AllianceGenome:HGNC:52383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP1; NPY4R; PPYR1; NPY4-R; CH17-360D5.1
Summary
Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 2.8), skin (RPKM 1.5) and 7 other tissues See more
Orthologs
all
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Genomic context

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Location:
10q11.22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47914243..47923524)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48761016..48772396)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 (PATCHES) NW_003871068.1 (2106924..2113420)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene annexin A8 Neighboring gene shieldin complex subunit 2 pseudogene 3 Neighboring gene uncharacterized LOC124902422 Neighboring gene uncharacterized LOC102724593 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 2 Neighboring gene synaptotagmin 15B Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47089387-47089886 Neighboring gene uncharacterized LOC124902423 Neighboring gene Sharpr-MPRA regulatory region 8752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47136815-47137314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47769223-47769865 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49196054-49197004 Neighboring gene NANOG hESC enhancer GRCh37_chr10:49202415-49202942 Neighboring gene family with sequence similarity 25 member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Yan H, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643460, Free PMC Article
  2. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. Bard JA, et al. J Biol Chem, 1995 Nov 10. PMID 7592911
  3. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. Lundell I, et al. J Biol Chem, 1995 Dec 8. PMID 7493937
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pancreatic polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neuropeptide Y receptor type 4-2
Names
Neuropeptide Y receptor type 4
Neuropeptide Y receptor type 4-2
Pancreatic polypeptide receptor 1
neuropeptide Y receptor Y42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278795.2 → NP_001265724.1  neuropeptide Y receptor type 4-2

    See identical proteins and their annotated locations for NP_001265724.1

    Status: VALIDATED

    Source sequence(s)
    AC245041
    Consensus CDS
    CCDS81459.1
    UniProtKB/Swiss-Prot
    P0DQD5
    UniProtKB/TrEMBL
    Q4KKW2
    Conserved Domains (1) summary
    cd15397
    Location:42 → 333
    7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001395253.1 → NP_001382182.1  neuropeptide Y receptor type 4-2

    Status: VALIDATED

    Source sequence(s)
    AC245041
    Consensus CDS
    CCDS81459.1
    UniProtKB/Swiss-Prot
    P0DQD5
    UniProtKB/TrEMBL
    Q4KKW2
    Related
    ENSP00000490174.1, ENST00000576178.7
    Conserved Domains (1) summary
    cd15397
    Location:42 → 333
    7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    47914243..47923524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015464.2 → XP_016870953.1  neuropeptide Y receptor type 4-2 isoform X1

    UniProtKB/Swiss-Prot
    P0DQD5
    UniProtKB/TrEMBL
    Q4KKW2
    Conserved Domains (1) summary
    cd15397
    Location:42 → 333
    7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_011539115.3 → XP_011537417.1  neuropeptide Y receptor type 4-2 isoform X1

    See identical proteins and their annotated locations for XP_011537417.1

    UniProtKB/Swiss-Prot
    P0DQD5
    UniProtKB/TrEMBL
    Q4KKW2
    Conserved Domains (1) summary
    cd15397
    Location:42 → 333
    7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_006717545.4 → XP_006717608.1  neuropeptide Y receptor type 4-2 isoform X1

    See identical proteins and their annotated locations for XP_006717608.1

    UniProtKB/Swiss-Prot
    P0DQD5
    UniProtKB/TrEMBL
    Q4KKW2
    Related
    ENSP00000489924.1, ENST00000613306.1
    Conserved Domains (1) summary
    cd15397
    Location:42 → 333
    7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160001.1 Reference GRCh38.p14 PATCHES

    Range
    130393..141806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332437.1 → XP_054188412.1  neuropeptide Y receptor type 4-2 isoform X1

    UniProtKB/Swiss-Prot
    P0DQD5

  2. XM_054332438.1 → XP_054188413.1  neuropeptide Y receptor type 4-2 isoform X1

    UniProtKB/Swiss-Prot
    P0DQD5

  3. XM_054332436.1 → XP_054188411.1  neuropeptide Y receptor type 4-2 isoform X1

    UniProtKB/Swiss-Prot
    P0DQD5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    48761016..48772396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364464.1 → XP_054220439.1  neuropeptide Y receptor type 4-2 isoform X1

  2. XM_054364467.1 → XP_054220442.1  neuropeptide Y receptor type 4-2 isoform X1

  3. XM_054364465.1 → XP_054220440.1  neuropeptide Y receptor type 4-2 isoform X1

  4. XM_054364466.1 → XP_054220441.1  neuropeptide Y receptor type 4-2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DQD5.1 GenPept UniProtKB/Swiss-Prot:P0DQD5

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