U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HSPG2 heparan sulfate proteoglycan 2 [ Felis catus (domestic cat) ]

Gene ID: 101094520, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
HSPG2
Official Full Name
heparan sulfate proteoglycan 2
Primary source
VGNC:VGNC:82439
See related
EnsemblRapid:ENSFCTG00005031503
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HSPG2 in Genome Data Viewer
Location:
chromosome: C1
Exon count:
99
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C1 NC_058375.1 (15990872..16090780, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C1 NC_018730.3 (16070729..16170453, complement)

Chromosome C1 - NC_058375.1Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein Neighboring gene uncharacterized LOC123379506 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene putative protein TPRXL Neighboring gene uncharacterized LOC102901553 Neighboring gene cytochrome c oxidase subunit NDUFA4-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
basement membrane-specific heparan sulfate proteoglycan core protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058375.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    15990872..16090780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045035257.1 → XP_044891192.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X7

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Conserved Domains (11) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1275 → 1322
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:985 → 1112
    LamB; Laminin B domain
    smart00409
    Location:3590 → 3667
    IG; Immunoglobulin
    smart00410
    Location:2054 → 2131
    IG_like; Immunoglobulin like
    cd00054
    Location:3861 → 3890
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1158 → 1207
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4212 → 4371
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:2065 → 2069
    Ig; Ig strand B [structural motif]

  2. XM_045035256.1 → XP_044891191.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X6

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Related
    ENSFCTP00005059472.1, ENSFCTT00005088150.1
    Conserved Domains (11) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1275 → 1322
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:985 → 1112
    LamB; Laminin B domain
    smart00409
    Location:3591 → 3668
    IG; Immunoglobulin
    smart00410
    Location:2055 → 2132
    IG_like; Immunoglobulin like
    cd00054
    Location:3862 → 3891
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1158 → 1207
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4213 → 4372
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:2066 → 2070
    Ig; Ig strand B [structural motif]

  3. XM_045035255.1 → XP_044891190.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X5

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Conserved Domains (11) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1282 → 1329
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:992 → 1119
    LamB; Laminin B domain
    smart00409
    Location:3598 → 3675
    IG; Immunoglobulin
    smart00410
    Location:1969 → 2049
    IG_like; Immunoglobulin like
    cd00054
    Location:3869 → 3898
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1165 → 1214
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4220 → 4379
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:1980 → 1984
    Ig; Ig strand B [structural motif]

  4. XM_045035254.1 → XP_044891189.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X4

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Conserved Domains (11) summary
    cd05743
    Location:424 → 501
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1285 → 1332
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:995 → 1122
    LamB; Laminin B domain
    smart00409
    Location:3601 → 3678
    IG; Immunoglobulin
    smart00410
    Location:1972 → 2052
    IG_like; Immunoglobulin like
    cd00054
    Location:3872 → 3901
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1168 → 1217
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4223 → 4382
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:288 → 322
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:1983 → 1987
    Ig; Ig strand B [structural motif]

  5. XM_045035253.1 → XP_044891188.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X3

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Related
    ENSFCTP00005059504.1, ENSFCTT00005088217.1
    Conserved Domains (11) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1292 → 1339
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 188
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1002 → 1129
    LamB; Laminin B domain
    smart00409
    Location:3608 → 3685
    IG; Immunoglobulin
    smart00410
    Location:1979 → 2059
    IG_like; Immunoglobulin like
    cd00054
    Location:3879 → 3908
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1175 → 1224
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4230 → 4389
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:1990 → 1994
    Ig; Ig strand B [structural motif]

  6. XM_045035252.1 → XP_044891187.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X2

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Conserved Domains (11) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1299 → 1346
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 188
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1009 → 1136
    LamB; Laminin B domain
    smart00409
    Location:3614 → 3691
    IG; Immunoglobulin
    smart00410
    Location:1985 → 2065
    IG_like; Immunoglobulin like
    cd00054
    Location:3885 → 3914
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1182 → 1231
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4236 → 4395
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:1996 → 2000
    Ig; Ig strand B [structural motif]

  7. XM_045035251.1 → XP_044891186.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Conserved Domains (11) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1299 → 1346
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 188
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1009 → 1136
    LamB; Laminin B domain
    smart00409
    Location:3615 → 3692
    IG; Immunoglobulin
    smart00410
    Location:1986 → 2066
    IG_like; Immunoglobulin like
    cd00054
    Location:3886 → 3915
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1182 → 1231
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4237 → 4396
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:1997 → 2001
    Ig; Ig strand B [structural motif]

  8. XM_045035258.1 → XP_044891193.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X8

    UniProtKB/TrEMBL
    A0A5F5Y6R8
    Conserved Domains (9) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00180
    Location:1299 → 1346
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:80 → 188
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1009 → 1136
    LamB; Laminin B domain
    smart00409
    Location:2478 → 2555
    IG; Immunoglobulin
    smart00410
    Location:3615 → 3692
    IG_like; Immunoglobulin like
    cd00055
    Location:1182 → 1231
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00096
    Location:3626 → 3630
    Ig; Ig strand B [structural motif]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.