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HIPK3 homeodomain interacting protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 10114, updated on 2-Nov-2024

Summary

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Official Symbol
HIPK3provided by HGNC
Official Full Name
homeodomain interacting protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:4915
See related
Ensembl:ENSG00000110422 MIM:604424; AllianceGenome:HGNC:4915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKY; YAK1; DYRK6; FIST3
Summary
Enables protein serine/threonine kinase activity. Involved in mRNA transcription; negative regulation of apoptotic process; and protein phosphorylation. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in fat (RPKM 29.7), gall bladder (RPKM 21.4) and 25 other tissues See more
Orthologs
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Genomic context

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See HIPK3 in Genome Data Viewer
Location:
11p13
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (33256672..33357023)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33392109..33492540)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33278218..33378569)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CSTF3 divergent transcript Neighboring gene ribosomal protein L29 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4576 Neighboring gene ribosomal protein S24 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3238 Neighboring gene KIAA1549 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33666983-33667484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33667485-33667984 Neighboring gene uncharacterized LOC105376617 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33676703-33677902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4582 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:33711673-33712872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3240 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene CD59 molecule (CD59 blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer. Wu QN, et al. Cancer Lett, 2024 Mar 1. PMID 38246220
  2. Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1. Begley DA, et al. Gene, 1997 Oct 24. PMID 9373137
  3. Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization. Nupponen NN, et al. Cytogenet Cell Genet, 1999. PMID 10640824
  4. HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease. Fu Y, et al. Autophagy, 2018. PMID 29130397, Free PMC Article
  5. CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer. Liu N, et al. Eur Rev Med Pharmacol Sci, 2018 Jun. PMID 29949144

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation.
    Title: CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation.
  2. HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer.
    Title: HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer.
  3. Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3.
    Title: Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3.
  4. CircHIPK3 relieves vascular calcification via mediating SIRT1/PGC-1alpha/MFN2 pathway by interacting with FUS.
    Title: CircHIPK3 relieves vascular calcification via mediating SIRT1/PGC-1α/MFN2 pathway by interacting with FUS.
  5. Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation.
    Title: Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation.
  6. DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammation.
    Title: DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammation.
  7. circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
    Title: circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
  8. Circ_0060,144 inhibits the occurrence and development of age-related cataract via the miR-23b-3p/HIPK3 axis.
    Title: Circ_0060,144 inhibits the occurrence and development of age-related cataract via the miR-23b-3p/HIPK3 axis.
  9. CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2.
    Title: CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2.
  10. CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1.
    Title: CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of proneness to anger.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
homeodomain-interacting protein kinase 3
Names
ANPK
FIST
androgen receptor-interacting nuclear protein kinase
fas-interacting serine/threonine-protein kinase
homolog of protein kinase YAK1
NP_001041665.1
NP_001265091.1
NP_001265092.1
NP_005725.3
XP_047282179.1
XP_047282180.1
XP_047282181.1
XP_054223402.1
XP_054223403.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048200.3 → NP_001041665.1  homeodomain-interacting protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001041665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AK315277, AL122015, BX117467, DR000092, HY053621
    Consensus CDS
    CCDS41634.1
    UniProtKB/TrEMBL
    A8KAE4
    Related
    ENSP00000368301.3, ENST00000379016.7
    Conserved Domains (2) summary
    smart00220
    Location:197 → 525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196 → 525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

  2. NM_001278162.2 → NP_001265091.1  homeodomain-interacting protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001265091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AK293009, AK315277, AL122015, AL136126, BX117467
    Consensus CDS
    CCDS41634.1
    UniProtKB/TrEMBL
    A8KAE4
    Related
    ENSP00000398241.1, ENST00000456517.2
    Conserved Domains (2) summary
    smart00220
    Location:197 → 525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196 → 525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

  3. NM_001278163.2 → NP_001265092.1  homeodomain-interacting protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001265092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AK315277, AL122015, BX117467
    Consensus CDS
    CCDS41634.1
    UniProtKB/TrEMBL
    A8KAE4
    Related
    ENSP00000431710.1, ENST00000525975.5
    Conserved Domains (2) summary
    smart00220
    Location:197 → 525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196 → 525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

  4. NM_005734.5 → NP_005725.3  homeodomain-interacting protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_005725.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF004849, AL122015, BX117467, DR000092, HY053621, Y09306
    Consensus CDS
    CCDS7884.1
    UniProtKB/Swiss-Prot
    O14632, Q2PBG4, Q2PBG5, Q92632, Q9H422, Q9HAS2
    UniProtKB/TrEMBL
    A8KAE4
    Related
    ENSP00000304226.4, ENST00000303296.9
    Conserved Domains (2) summary
    smart00220
    Location:197 → 525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14229
    Location:196 → 525
    STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    33256672..33357023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426223.1 → XP_047282179.1  homeodomain-interacting protein kinase 3 isoform X2

  2. XM_047426224.1 → XP_047282180.1  homeodomain-interacting protein kinase 3 isoform X3

  3. XM_047426225.1 → XP_047282181.1  homeodomain-interacting protein kinase 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    33392109..33492540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367427.1 → XP_054223402.1  homeodomain-interacting protein kinase 3 isoform X4

    UniProtKB/Swiss-Prot
    O14632, Q2PBG4, Q2PBG5, Q92632, Q9H422, Q9HAS2

  2. XM_054367428.1 → XP_054223403.1  homeodomain-interacting protein kinase 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H422.1 GenPept UniProtKB/Swiss-Prot:Q9H422

Gene LinkOut

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