PANDAR promoter of CDKN1A antisense DNA damage activated RNA [Homo sapiens (human)] - Gene

Summary

Official Symbol: PANDARprovided by HGNC
Official Full Name: promoter of CDKN1A antisense DNA damage activated RNAprovided by HGNC
Primary source: HGNC:HGNC:44048
See related: Ensembl:ENSG00000281450 MIM:617179; AllianceGenome:HGNC:44048
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PANDA
Summary: This gene produces a non-coding RNA that is thought to regulate the response to DNA damage. This gene is induced by tumor protein p53 and interacts with and modulates the activity of a transcription factor that induce pro-apoptotic genes. Deregulation of this gene is associated with cancer progression. [provided by RefSeq, Dec 2017]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 6p21.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (36673621..36675126, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (36494265..36495770, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (36641398..36642903, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The long non-coding RNA PANDAR regulates cell proliferation and epithelial-to-mesenchymal transition in glioma.
Title: The long non-coding RNA PANDAR regulates cell proliferation and epithelial-to-mesenchymal transition in glioma.
Knockdown of lincRNA PADNA promotes bupivacaine-induced neurotoxicity by miR-194/FBXW7 axis.
Title: Knockdown of lincRNA PADNA promotes bupivacaine-induced neurotoxicity by miR-194/FBXW7 axis.
The cisplatin-induced long non-coding RNA PANDAR dictates the chemoresistance of ovarian cancer via regulating SFRS2-mediated p53 phosphorylation.
Title: The cisplatin-induced lncRNA PANDAR dictates the chemoresistance of ovarian cancer via regulating SFRS2-mediated p53 phosphorylation.
we showed that lncRNA PANDAR expression was upregulated in breast cancer tissues and cells. Furthermore, we demonstrated that lncRNA PANDAR knockdown inhibited cell proliferation, cell invasion ability and EMT signaling pathway in breast cancer.
Title: Inhibition of lncRNA PANDAR reduces cell proliferation, cell invasion and suppresses EMT pathway in breast cancer.
Over-expression of LncRNA PANDAR was indicared to be effectively predictive of cancer progression [Meta-analysis].
Title: LncRNA PANDAR is a Novel Prognostic Biomarker in Patients with Cancer: a Meta-Analysis.
Authors observed that overexpression of PANDAR leads to a reduced level of the short pro-apoptotic BCL-X splice variant (BCL-XS) which is regulated by PTBP1. Simultaneous overexpression of PTBP1 was able to rescue this effect.
Title: Identification of novel PANDAR protein interaction partners involved in splicing regulation.
PANDAR controlled the transcription of the CDKN1A gene by competitively binding with p53 protein.
Title: Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer.
PANDA repressed transcriptional activity of senescence associated inflammatory factor IL8, which leaded to inhibition of cellular senescence.
Title: Over Expression of Long Non-Coding RNA PANDA Promotes Hepatocellular Carcinoma by Inhibiting Senescence Associated Inflammatory Factor IL8.
This study demonstrated that the PANDAR significantly over-expressed in MS patients compared with healthy subjects.
Title: Dysregulation of long non-coding RNA profile in peripheral blood of multiple sclerosis patients.
The knockdown of PANDAR expression significantly inhibited the proliferation of cervical cancer cells.
Title: Upregulation of LncRNA PANDAR predicts poor prognosis and promotes cell proliferation in cervical cancer.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Other Names

p21 associated ncRNA DNA damage activated

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.