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ARL4A ARF like GTPase 4A [ Homo sapiens (human) ]

Gene ID: 10124, updated on 19-Sep-2024

Summary

Official Symbol
ARL4Aprovided by HGNC
Official Full Name
ARF like GTPase 4Aprovided by HGNC
Primary source
HGNC:HGNC:695
See related
Ensembl:ENSG00000122644 MIM:604786; AllianceGenome:HGNC:695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL4
Summary
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 32.8), bone marrow (RPKM 17.5) and 24 other tissues See more
Orthologs
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Genomic context

See ARL4A in Genome Data Viewer
Location:
7p21.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (12686903..12690958)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (12817976..12822031)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (12726528..12730583)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375157 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:12714709-12715908 Neighboring gene apoptosis-inducing, TAF9-like domain 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17979 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:12726767-12727303 Neighboring gene small nucleolar RNA SNORA64/SNORA10 family Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:12755219-12755886 Neighboring gene CRISPRi-validated cis-regulatory element chr7.1000 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:12768729-12769252 Neighboring gene NANOG hESC enhancer GRCh37_chr7:12860349-12860942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:12879421-12879981 Neighboring gene RN7SK pseudogene 228

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 4A
Names
ADP ribosylation factor like GTPase 4A
ADP-ribosylation factor-like 4
ADP-ribosylation factor-like 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037164.3NP_001032241.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_001032241.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC011891, DB472672
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    A4D119, P40617, P80418, Q49AF5
    Related
    ENSP00000349250.3, ENST00000356797.7
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  2. NM_001195396.2NP_001182325.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_001182325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC011891, AU076407, BQ948724
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    A4D119, P40617, P80418, Q49AF5
    Related
    ENSP00000385236.1, ENST00000404894.1
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  3. NM_005738.5NP_005729.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_005729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC011891, BQ948724
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    A4D119, P40617, P80418, Q49AF5
    Related
    ENSP00000498350.1, ENST00000651779.1
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases
  4. NM_212460.4NP_997625.1  ADP-ribosylation factor-like protein 4A

    See identical proteins and their annotated locations for NP_997625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC011891, DB451189
    Consensus CDS
    CCDS5359.1
    UniProtKB/Swiss-Prot
    A4D119, P40617, P80418, Q49AF5
    Related
    ENSP00000379899.2, ENST00000396664.2
    Conserved Domains (1) summary
    cd04152
    Location:18200
    Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    12686903..12690958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    12817976..12822031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)