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Dhx32 DEAH-box helicase 32 (putative) [ Mus musculus (house mouse) ]

Gene ID: 101437, updated on 2-Nov-2024

Summary

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Official Symbol
Dhx32provided by MGI
Official Full Name
DEAH-box helicase 32 (putative)provided by MGI
Primary source
MGI:MGI:2141813
See related
Ensembl:ENSMUSG00000030986 AllianceGenome:MGI:2141813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ddx32; muDDX32; 4732469F02Rik
Summary
Predicted to enable RNA binding activity and helicase activity. Predicted to be located in mitochondrion and nucleus. Predicted to be part of spliceosomal complex. Orthologous to human DHX32 (DEAH-box helicase 32 (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 23.6), placenta adult (RPKM 18.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx32 in Genome Data Viewer
Location:
7 F3; 7 77.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133322671..133384514, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133720935..133782785, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4982 Neighboring gene STARR-positive B cell enhancer ABC_E10481 Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene STARR-seq mESC enhancer starr_20333 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene predicted gene 15483 Neighboring gene fibronectin type 3 and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_20336 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene predicted gene, 51500 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 39103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of murine Dhx32. Alli Z, et al. Exp Mol Pathol, 2007 Aug. PMID 17239371
  2. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. Abdelhaleem M. Leuk Res, 2002 Oct. PMID 12163057
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 3110079L04Rik, 4732469F02Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
Names
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
DEAH box protein 32
helicase DDX32
NP_001272959.2
NP_001272960.2
NP_001272961.1
NP_001344614.2
NP_001390352.1
NP_001390353.1
NP_001390354.1
NP_598702.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286030.2 → NP_001272959.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
    Source sequence(s)
    AC127348
    Consensus CDS
    CCDS21936.1
    UniProtKB/Swiss-Prot
    Q3TFU4, Q8BZS9, Q8VH39, Q922N6
    Related
    ENSMUST00000140593.9

  2. NM_001286031.2 → NP_001272960.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
    Source sequence(s)
    AC127348
    Consensus CDS
    CCDS21936.1
    UniProtKB/Swiss-Prot
    Q3TFU4, Q8BZS9, Q8VH39, Q922N6
    Related
    ENSMUSP00000066067.3, ENSMUST00000063669.8

  3. NM_001286032.2 → NP_001272961.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform b

    See identical proteins and their annotated locations for NP_001272961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks the exon containing the translation start codon and therefore uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC127348
    Consensus CDS
    CCDS72060.1
    UniProtKB/TrEMBL
    D3Z4E3
    Related
    ENSMUSP00000101745.2, ENSMUST00000106139.8
    Conserved Domains (3) summary
    smart00847
    Location:332 → 416
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:1 → 547
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam07717
    Location:457 → 564
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  4. NM_001357685.2 → NP_001344614.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter when compared to isoform a. Variants 5 and 6 encode the same isoform (c).
    Source sequence(s)
    AC127348

  5. NM_001403423.1 → NP_001390352.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: Variants 5 and 6 encode the same isoform (c).
    Source sequence(s)
    AC127348

  6. NM_001403424.1 → NP_001390353.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
    Source sequence(s)
    AC127348
    UniProtKB/Swiss-Prot
    Q3TFU4, Q8BZS9, Q8VH39, Q922N6

  7. NM_001403425.1 → NP_001390354.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
    Source sequence(s)
    AC127348
    UniProtKB/Swiss-Prot
    Q3TFU4, Q8BZS9, Q8VH39, Q922N6

  8. NM_133941.3 → NP_598702.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 7 and 8, all encode the same isoform (a).
    Source sequence(s)
    AC127348
    Consensus CDS
    CCDS21936.1
    UniProtKB/Swiss-Prot
    Q3TFU4, Q8BZS9, Q8VH39, Q922N6
    Related
    ENSMUSP00000033290.7, ENSMUST00000033290.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    133322671..133384514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZS9.2 GenPept UniProtKB/Swiss-Prot:Q8BZS9

Gene LinkOut

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