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Hbb-bt hemoglobin, beta adult t chain [ Mus musculus (house mouse) ]

Gene ID: 101488143, updated on 28-Oct-2024

Summary

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Official Symbol
Hbb-btprovided by MGI
Official Full Name
hemoglobin, beta adult t chainprovided by MGI
Primary source
MGI:MGI:5474850
See related
Ensembl:ENSMUSG00000073940 AllianceGenome:MGI:5474850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Beta-t
Summary
This gene encodes a beta polypeptide chain found in adult hemoglobin, which consists of a tetramer of two alpha chains and two beta chains, and which functions in the transport of oxygen to various peripheral tissues. This gene is one of a cluster of beta-hemoglobin genes that are distally regulated by a locus control region, and which are organized along the chromosome in the order of their developmental expression. In mouse, two major strain-specific haplotypes of the beta-globin gene cluster are found - a "single" haplotype found in C57BL/-type strains, which includes two highly similar adult beta-globin genes, beta s and beta t, and a "diffuse" haplotype found in strains such as BALB/c and 129Sv, which includes two somewhat diverse adult beta-globin genes, beta-major and beta-minor. This gene represents the beta t adult gene found in the "single" haplotype. Primary chromosome 7 of the mouse reference genome assembly, which is derived from C57BL/6 strain mice, represents the "single" haplotype, while the "diffuse" haplotype is represented in the reference genome collection by the BALB/c strain alternate contig, NT_095534.1. [provided by RefSeq, May 2013]
Expression
Biased expression in spleen adult (RPKM 21891.7), heart adult (RPKM 7869.6) and 3 other tissues See more
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Genomic context

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See Hbb-bt in Genome Data Viewer
Location:
7 E3; 7
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103461731..103463130, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (103812524..103813923, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily A member 5 Neighboring gene olfactory receptor family 52 subfamily Z member 1 Neighboring gene beta-globin 3' hypersensitive site 1 Neighboring gene beta2-globin 3' enhancer Neighboring gene STARR-positive B cell enhancer ABC_E10458 Neighboring gene STARR-positive B cell enhancer ABC_E6577 Neighboring gene B1-559 region downstream of beta(major)-globin gene Neighboring gene beta1-globin 3' enhancer Neighboring gene hemoglobin, beta adult s chain Neighboring gene predicted gene 15115

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolution of duplicated beta-globin genes and the structural basis of hemoglobin isoform differentiation in Mus. Runck AM, et al. Mol Biol Evol, 2009 Nov. PMID 19675095, Free PMC Article
  2. Complex signatures of selection and gene conversion in the duplicated globin genes of house mice. Storz JF, et al. Genetics, 2007 Sep. PMID 17660536, Free PMC Article
  3. An unmethylated 3' promoter-proximal region is required for efficient transcription initiation. Appanah R, et al. PLoS Genet, 2007 Feb 16. PMID 17305432, Free PMC Article
  4. Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Ghanem LR, et al. Mol Cell Biol, 2018 Aug 15. PMID 29866654, Free PMC Article
  5. The adult beta-globin genes of the "single" type mouse C57BL. Weaver S, et al. Cell, 1981 May. PMID 7237554

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to haptoglobin binding ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hemoglobin alpha binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hemoglobin alpha binding ISO
Inferred from Sequence Orthology
more info
  
enables hemoglobin beta binding ISO
Inferred from Sequence Orthology
more info
  
enables hemoglobin binding ISO
Inferred from Sequence Orthology
more info
  
enables organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to oxygen binding ISO
Inferred from Sequence Orthology
more info
  
enables oxygen binding ISO
Inferred from Sequence Orthology
more info
  
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to peroxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of haptoglobin-hemoglobin complex ISO
Inferred from Sequence Orthology
more info
  
part_of hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
hemoglobin, beta adult t chain
Names
beta t

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008220.5 → NP_032246.2  hemoglobin, beta adult t chain

    See identical proteins and their annotated locations for NP_032246.2

    Status: VALIDATED

    Source sequence(s)
    AK012551, AK028067
    Consensus CDS
    CCDS40060.1
    UniProtKB/TrEMBL
    A8DUK4, A8DUK7, A8DUL2, A8DUL7, A8DUN2, A8DUQ1
    Related
    ENSMUSP00000095794.4, ENSMUST00000098192.4
    Conserved Domains (1) summary
    cd08925
    Location:7 → 146
    Hb-beta_like; Hemoglobin beta, gamma, delta, epsilon, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    103461731..103463130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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