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Mob2 MOB kinase activator 2 [ Mus musculus (house mouse) ]

Gene ID: 101513, updated on 2-Nov-2024

Summary

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Official Symbol
Mob2provided by MGI
Official Full Name
MOB kinase activator 2provided by MGI
Primary source
MGI:MGI:1919891
See related
Ensembl:ENSMUSG00000025147 AllianceGenome:MGI:1919891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mmh; 1110017M21Rik; 2700078K21Rik
Summary
Predicted to enable protein kinase activator activity. Acts upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytoplasm and neuron projection terminus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 13.7), colon adult (RPKM 11.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mob2 in Genome Data Viewer
Location:
7 F5; 7 87.5 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141562254..141614796, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142008517..142061059, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20497 Neighboring gene predicted gene, 32539 Neighboring gene BR serine/threonine kinase 2 Neighboring gene microRNA 3104 Neighboring gene STARR-seq mESC enhancer starr_20498 Neighboring gene predicted gene, 25416 Neighboring gene dual specificity phosphatase 8 Neighboring gene predicted gene, 57785

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein. Lin CH, et al. FEBS Lett, 2011 Feb 4. PMID 21237165
  2. JADE2 Is Essential for Hippocampal Synaptic Plasticity and Cognitive Functions in Mice. Fan M, et al. Biol Psychiatry, 2022 Nov 15. PMID 36008159
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MOB kinase activator 2
Names
Mps one binder kinase activator-like 2
mob2 homolog
ovary-specific MOB-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347560.1 → NP_001334489.1  MOB kinase activator 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL603836
    Consensus CDS
    CCDS85460.1
    UniProtKB/TrEMBL
    Q3TYF8
    Related
    ENSMUSP00000147608.2, ENSMUST00000211206.2
    Conserved Domains (1) summary
    pfam03637
    Location:5 → 115
    Mob1_phocein; Mob1/phocein family

  2. NM_001357705.1 → NP_001344634.1  MOB kinase activator 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate, frame-shifting splice site in the 3' coding region compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL603836
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 140
    Mob1_phocein; Mob1/phocein family

  3. NM_001374635.1 → NP_001361564.1  MOB kinase activator 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AL603836
    Consensus CDS
    CCDS90353.1
    UniProtKB/TrEMBL
    A0A1B0GR18
    Related
    ENSMUSP00000147340.2, ENSMUST00000209732.2
    Conserved Domains (1) summary
    pfam03637
    Location:63 → 231
    Mob1_phocein; Mob1/phocein family

  4. NM_001382351.1 → NP_001369280.1  MOB kinase activator 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603836
    UniProtKB/TrEMBL
    Q3TYF8
    Related
    ENSMUSP00000147643.2, ENSMUST00000211000.2
    Conserved Domains (1) summary
    pfam03637
    Location:5 → 115
    Mob1_phocein; Mob1/phocein family

  5. NM_028308.2 → NP_082584.1  MOB kinase activator 2 isoform 1

    See identical proteins and their annotated locations for NP_082584.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the isoform 1.
    Source sequence(s)
    AL603836
    Consensus CDS
    CCDS40190.1
    UniProtKB/Swiss-Prot
    Q3UXL5, Q8VI63, Q9CZJ5
    Related
    ENSMUSP00000081455.3, ENSMUST00000084418.4
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 200
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141562254..141614796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152537.1 → XP_036008430.1  MOB kinase activator 2 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GR18
    Conserved Domains (1) summary
    pfam03637
    Location:63 → 231
    Mob1_phocein; Mob1/phocein family

  2. XM_036152538.1 → XP_036008431.1  MOB kinase activator 2 isoform X3

    UniProtKB/TrEMBL
    Q3TYF8
    Conserved Domains (1) summary
    pfam03637
    Location:5 → 115
    Mob1_phocein; Mob1/phocein family

  3. XM_011241972.4 → XP_011240274.1  MOB kinase activator 2 isoform X2

    Conserved Domains (1) summary
    pfam03637
    Location:63 → 171
    Mob1_phocein; Mob1/phocein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VI63.1 GenPept UniProtKB/Swiss-Prot:Q8VI63

Gene LinkOut

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